Buchumschlag

Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion

Plasmodium falciparum merozoites expose at their surface a large protein complex, which is composed of fragments of merozoite surface protein 1 (MSP-1; called MSP-183, MSP-130, MSP-138, and MSP-142) plus associated processing products of MSP-6 and MSP-7. During erythrocyte invasion this complex, as...

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Bibliographische Detailangaben
Hauptverfasser: Wöhlbier, Ute (VerfasserIn) , Epp, Christian (VerfasserIn) , Hackett, Fiona (VerfasserIn) , Blackman, Michael J. (VerfasserIn) , Bujard, Hermann (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 18 March 2010
In: Malaria journal
Year: 2010, Jahrgang: 9, Heft: 1, Pages: 1-12
ISSN:1475-2875
DOI:10.1186/1475-2875-9-77
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1475-2875-9-77
Volltext
Verfasserangaben:Ute Woehlbier, Christian Epp, Fiona Hackett, Michael J. Blackman, Hermann Bujard
Beschreibung
Zusammenfassung:Plasmodium falciparum merozoites expose at their surface a large protein complex, which is composed of fragments of merozoite surface protein 1 (MSP-1; called MSP-183, MSP-130, MSP-138, and MSP-142) plus associated processing products of MSP-6 and MSP-7. During erythrocyte invasion this complex, as well as an integral membrane protein called apical membrane antigen-1 (AMA-1), is shed from the parasite surface following specific proteolysis. Components of the MSP-1/6/7 complex and AMA-1 are presently under development as malaria vaccines.
Beschreibung:Gesehen am 15.03.2024
Beschreibung:Online Resource
ISSN:1475-2875
DOI:10.1186/1475-2875-9-77

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