Cover Image

Update on calcitonin screening for medullary thyroid carcinoma and the results of a retrospective analysis of 12,984 patients with thyroid nodules

Background: We provide an update on calcitonin (Ctn) screening for the early detection of medullary thyroid carcinoma (MTC) and present the results of a large single-center analysis evaluating sex-specific cut-off-levels and long-term courses. Methods: A total of 12,984 consecutive adult patients (2...

Full description

Saved in:
Bibliographic Details
Main Authors: Bröcker, Martina (Author) , Simon, Dietmar (Author) , Fries, Mirka (Author) , Kornely, Elisabeth (Author) , Weber, Manuel (Author) , Vardarli, Irfan (Author) , Gilman, Elena (Author) , Herrmann, Ken (Author) , Görges, Rainer (Author)
Format: Article (Journal)
Language:English
Published: 17 April 2023
In: Cancers
Year: 2023, Volume: 15, Issue: 8, Pages: 1-20
ISSN:2072-6694
DOI:10.3390/cancers15082333
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers15082333
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/15/8/2333
Get full text
Author Notes:Martina Broecker-Preuss, Dietmar Simon, Mirka Fries, Elisabeth Kornely, Manuel Weber, Irfan Vardarli, Elena Gilman, Ken Herrmann and Rainer Görges
Description
Summary:Background: We provide an update on calcitonin (Ctn) screening for the early detection of medullary thyroid carcinoma (MTC) and present the results of a large single-center analysis evaluating sex-specific cut-off-levels and long-term courses. Methods: A total of 12,984 consecutive adult patients (20.1% male and 79.9% female) with thyroid nodules who had undergone routine Ctn measurement were retrospectively analyzed. Patients with confirmed suspicious Ctn values were referred for surgery. Results: Ctn measurements were elevated in 207 (1.6%) patients, with values below twice the sex-specific reference limit in 82% of these cases. Further clarification was possible in 124/207 cases, of which MTC could be ruled out in 108 cases. Histopathological assessment confirmed MTC in 16/12,984 patients. Conclusions: Our extrapolated MTC prevalence of 0.14% is significantly lower than that described in early international screening studies. The stimulation test can usually be dispensable when using a decision-making concept based on sex-specific basal Ctn cut-off values. Ctn screening is recommended even in patients with very small thyroid nodules. High quality standards in pre-analytics, laboratory measurements, and the interpretation of data must be ensured, as well as close interdisciplinary cooperation between medical disciplines.
Item Description:Gesehen am 19.03.2024
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers15082333

Similar Items