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Study protocol: a pragmatic, cluster-randomized controlled trial to evaluate the effect of implementation of the Truenat platform/MTB assays at primary health care clinics in Mozambique and Tanzania (TB-CAPT CORE)

In 2020, the WHO-approved Molbio Truenat platform and MTB assays to detect Mycobacterium tuberculosis complex (MTB) and resistance to rifampicin directly on sputum specimens. This primary health care center-based trial in Mozambique and Tanzania investigates the effect of Truenat platform/MTB assays...

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Main Authors: Leukes, Vinzeigh (Author) , Hella, J. (Author) , Sabi, I. (Author) , Cossa, M. (Author) , Khosa, C. (Author) , Erkosar, B. (Author) , Mangu, C. (Author) , Siyame, E. (Author) , Mtafya, B. (Author) , Lwilla, A. (Author) , Viegas, S. (Author) , Madeira, C. (Author) , Machiana, A. (Author) , Ribeiro, J. (Author) , Garcia-Basteiro, A. L. (Author) , Riess, F. (Author) , Elísio, D. (Author) , Sasamalo, M. (Author) , Mhalu, G. (Author) , Denkinger, Claudia M. (Author) , Castro, María del Mar (Author) , Bashir, S. (Author) , Schumacher, S. G. (Author) , Tagliani, E. (Author) , Malhotra, A. (Author) , Dowdy, D. (Author) , Schacht, C. (Author) , Buech, J. (Author) , Nguenha, D. (Author) , Ntinginya, N. (Author) , Ruhwald, M. (Author) , Penn-Nicholson, A. (Author) , Kranzer, K. (Author)
Format: Article (Journal)
Language:English
Published: 19 January 2024
In: BMC infectious diseases
Year: 2024, Volume: 24, Issue: 1, Pages: 1-12
ISSN:1471-2334
DOI:10.1186/s12879-023-08876-8
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12879-023-08876-8
Verlag, kostenfrei, Volltext: https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-023-08876-8
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Author Notes:V. N. Leukes, J. Hella, I. Sabi, M. Cossa, C. Khosa, B. Erkosar, C. Mangu, E. Siyame, B. Mtafya, A. Lwilla, S. Viegas, C. Madeira, A. Machiana, J. Ribeiro, A. L. Garcia-Basteiro, F. Riess, D. Elísio, M. Sasamalo, G. Mhalu, C. M. Denkinger, M. D. M. Castro, S. Bashir, S. G. Schumacher, E. Tagliani, A. Malhotra, D. Dowdy, C. Schacht, J. Buech, D. Nguenha, N. Ntinginya, M. Ruhwald, A. Penn-Nicholson, K. Kranzer & TB-CAPT Consortium
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Summary:In 2020, the WHO-approved Molbio Truenat platform and MTB assays to detect Mycobacterium tuberculosis complex (MTB) and resistance to rifampicin directly on sputum specimens. This primary health care center-based trial in Mozambique and Tanzania investigates the effect of Truenat platform/MTB assays (intervention arm) combined with rapid communication of results compared to standard of care on TB diagnosis and treatment initiation for microbiologically confirmed TB at 7 days from enrolment.
Item Description:Gesehen am 19.03.2024
Physical Description:Online Resource
ISSN:1471-2334
DOI:10.1186/s12879-023-08876-8

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