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Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma

Aims and methods The aims of this study were to evaluate the prognostic impact of cytomorphology and three-tiered grading on tumour-free survival of patients with conventional renal cell carcinoma (cRCC). Formalin-fixed, paraffin-embedded samples from 710 patients were assessed and the results were...

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Bibliographic Details
Main Authors: Domonkos, Lilla (Author) , Yusenko, Maria (Author) , Kovacs, Gyula (Author) , Peterfi, Lehel (Author)
Format: Article (Journal)
Language:English
Published: March 20, 2024
In: Journal of clinical pathology
Year: 2024, Volume: 77, Issue: 4, Pages: 246-250
ISSN:1472-4146
DOI:10.1136/jcp-2023-209094
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jcp-2023-209094
Verlag, lizenzpflichtig, Volltext: https://jcp.bmj.com/content/77/4/246
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Author Notes:Lilla Domonkos, Maria Yusenko, Gyula Kovacs, Lehel Peterfi
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Summary:Aims and methods The aims of this study were to evaluate the prognostic impact of cytomorphology and three-tiered grading on tumour-free survival of patients with conventional renal cell carcinoma (cRCC). Formalin-fixed, paraffin-embedded samples from 710 patients were assessed and the results were evaluated according to the clinical data. - Results Kaplan-Meier regression model showed that 90.9% of patients with clear cell, and 50.9% with pure eosinophilic cRCC were free of metastasis during follow-up. The three-triered grading showed a good correlation with progression as 95.2% of patients with of G1 tumours, 66.1% with G2 tumours and only 25.3% with G3 tumours were tumour free (p<0.001). The grading was correlated with cytomorphology and coagulation necrosis. In multivariate analysis, tumour grade and stage were independent prognostic markers (p<0.001). - Conclusions The three-tiered grading predicts the progression of cRCC irrespectively of cytomorphology. However, the cytomorphology and necrosis show a good correlation with three-tiered grading in estimate disease progression.
Item Description:Zuerst veröffentlicht: 19. Dezember 2023
Gesehen am 22.03.2024
Physical Description:Online Resource
ISSN:1472-4146
DOI:10.1136/jcp-2023-209094

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