Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
Aims and methods The aims of this study were to evaluate the prognostic impact of cytomorphology and three-tiered grading on tumour-free survival of patients with conventional renal cell carcinoma (cRCC). Formalin-fixed, paraffin-embedded samples from 710 patients were assessed and the results were...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 20, 2024
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| In: |
Journal of clinical pathology
Year: 2024, Jahrgang: 77, Heft: 4, Pages: 246-250 |
| ISSN: | 1472-4146 |
| DOI: | 10.1136/jcp-2023-209094 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/jcp-2023-209094 Verlag, lizenzpflichtig, Volltext: https://jcp.bmj.com/content/77/4/246 
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| Verfasserangaben: | Lilla Domonkos, Maria Yusenko, Gyula Kovacs, Lehel Peterfi |
| Zusammenfassung: | Aims and methods The aims of this study were to evaluate the prognostic impact of cytomorphology and three-tiered grading on tumour-free survival of patients with conventional renal cell carcinoma (cRCC). Formalin-fixed, paraffin-embedded samples from 710 patients were assessed and the results were evaluated according to the clinical data. - Results Kaplan-Meier regression model showed that 90.9% of patients with clear cell, and 50.9% with pure eosinophilic cRCC were free of metastasis during follow-up. The three-triered grading showed a good correlation with progression as 95.2% of patients with of G1 tumours, 66.1% with G2 tumours and only 25.3% with G3 tumours were tumour free (p<0.001). The grading was correlated with cytomorphology and coagulation necrosis. In multivariate analysis, tumour grade and stage were independent prognostic markers (p<0.001). - Conclusions The three-tiered grading predicts the progression of cRCC irrespectively of cytomorphology. However, the cytomorphology and necrosis show a good correlation with three-tiered grading in estimate disease progression. |
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| Beschreibung: | Zuerst veröffentlicht: 19. Dezember 2023 Gesehen am 22.03.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1472-4146 |
| DOI: | 10.1136/jcp-2023-209094 |