Identification of CT imaging phenotypes of colorectal liver metastases from radiomics signatures: towards assessment of interlesional tumor heterogeneity
(1) Background: Tumoral heterogeneity (TH) is a major challenge in the treatment of metastatic colorectal cancer (mCRC) and is associated with inferior response. Therefore, the identification of TH would be beneficial for treatment planning. TH can be assessed by identifying genetic alterations. In...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 March 2022
|
| In: |
Cancers
Year: 2022, Volume: 14, Issue: 7, Pages: 1-13 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers14071646 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers14071646 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/14/7/1646 
|
| Author Notes: | Hishan Tharmaseelan, Alexander Hertel, Fabian Tollens, Johann Rink, Piotr Woźnicki, Verena Haselmann, Isabelle Ayx, Dominik Nörenberg, Stefan O. Schoenberg and Matthias F. Froelich |
| Summary: | (1) Background: Tumoral heterogeneity (TH) is a major challenge in the treatment of metastatic colorectal cancer (mCRC) and is associated with inferior response. Therefore, the identification of TH would be beneficial for treatment planning. TH can be assessed by identifying genetic alterations. In this work, a radiomics-based approach for assessment of TH in colorectal liver metastases (CRLM) in CT scans is demonstrated. (2) Methods: In this retrospective study, CRLM of mCRC were segmented and radiomics features extracted using pyradiomics. Unsupervised k-means clustering was applied to features and lesions. Feature redundancy was evaluated by principal component analysis and reduced by Pearson correlation coefficient cutoff. Feature selection was conducted by LASSO regression and visual analysis of the clusters by radiologists. (3) Results: A total of 47 patients’ (36% female, median age 64) CTs with 261 lesions were included. Five clusters were identified, and the categories small disseminated (n = 31), heterogeneous (n = 105), homogeneous (n = 64), mixed (n = 59), and very large type (n = 2) were assigned based on visual characteristics. Further statistical analysis showed correlation (p < 0.01) of clusters with sex, primary location, T- and N-status, and mutational status. Feature reduction and selection resulted in the identification of four features as a final set for cluster definition. (4) Conclusions: Radiomics features can characterize TH in liver metastases of mCRC in CT scans, and may be suitable for a better pretherapeutic classification of liver lesion phenotypes. |
|---|---|
| Item Description: | Gesehen am 26.03.2024 |
| Physical Description: | Online Resource |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers14071646 |