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BPSD patterns in patients with severe neuropsychiatric disturbances: insight from the RECAGE study: brief report

Objective - Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD. - Methods - We analyzed data collected at baseline in 398 patients with severe B...

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Main Authors: Cognat, Emmanuel (Author) , Sabia, Séverine (Author) , Fayel, Alexandra (Author) , Lilamand, Matthieu (Author) , Handels, Ron (Author) , Fascendini, Sara (Author) , Bergh, Sverre (Author) , Frisoni, Giovanni B. (Author) , Fabbo, Andrea (Author) , Tsolaki, Magdalina (Author) , Frölich, Lutz (Author) , Peters, Oliver (Author) , Merlo, Paola (Author) , Ciccone, Alfonso (Author) , Mecocci, Patrizia (Author) , Dumurgier, Julien (Author) , Defanti, Carlo A. (Author) , Hugon, Jacques (Author) , Paquet, Claire (Author)
Format: Article (Journal)
Language:English
Published: August 2023
In: American journal of geriatric psychiatry
Year: 2023, Volume: 31, Issue: 8, Pages: 633-639
ISSN:1545-7214
DOI:10.1016/j.jagp.2023.03.014
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jagp.2023.03.014
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1064748123002658
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Author Notes:Emmanuel Cognat, M.D., Ph.D., Séverine Sabia, Ph.D., Alexandra Fayel, Ph.D., Matthieu Lilamand, M.D., Ph.D., Ron Handels, Ph.D., Sara Fascendini, M.D., Ph.D., Sverre Bergh, M.D., Ph.D., Giovanni B. Frisoni, M.D., Ph.D., Andrea Fabbo, M.D., Magdalina Tsolaki, M.D., Lutz Frölich, M.D., Ph.D., Oliver Peters, M.D., Ph.D., Paola Merlo, M.D., Ph.D., Alfonso Ciccone, M.D., Patrizia Mecocci, M.D., Ph.D., Julien Dumurgier, M.D., Ph.D., Carlo A. Defanti, M.D., Ph.D., Jacques Hugon, M.D., Ph.D., Claire Paquet, M.D., Ph.D.
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Summary:Objective - Behavioral and psychological symptoms of dementia (BPSD) profiles vary depending on etiology in patients with mild-to-moderate BPSD. It is not known if similar differences exist in patients with severe BPSD. - Methods - We analyzed data collected at baseline in 398 patients with severe BPSD (NPI ≥ 32) and defined diagnosis of dementia (Alzheimer's disease [AD] 297; frontotemporal dementia [FTD] 39; Lewy body disease/Parkinsonian dementia [LBD/PD] 31; and vascular dementia [VD] 31) included in the European multicenter cohort RECAGE. - Results - Mean total NPI was 52.11 (18.55). LBD/PD patients demonstrated more hallucinations, more anxiety and more delusions than patients with other dementia. FTD patients had less delusions and more disinhibition than patients with other neurodegenerative disorders. These profiles overlapped partially with those reported in the literature in patients with less severe symptoms. - Conclusion - Patients with severe BPSD display different and specific profiles of neuropsychiatric symptoms depending on dementia etiology.
Item Description:Online verfügbar: 23. April 2023, Artikelversion: 29. Juni 2023
Gesehen am 28.03.2024
Physical Description:Online Resource
ISSN:1545-7214
DOI:10.1016/j.jagp.2023.03.014

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