Gunn's dots as indicators of renal function, findings from the tongren health care study
Purpose: To investigate the prevalence of Gunn's dots (GDs) and associated systemic factors in adult Chinese. Methods: A cross-sectional study enrolling participants older than 45 years from a community-based study. Gunn's dots were evaluated using fundus photography, and associated system...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 2022
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| In: |
Retina
Year: 2022, Volume: 42, Issue: 4, Pages: 789-796 |
| ISSN: | 1539-2864 |
| DOI: | 10.1097/IAE.0000000000003354 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/IAE.0000000000003354 Verlag, lizenzpflichtig, Volltext: http://journals.lww.com/retinajournal/abstract/2022/04000/gunn_s_dots_as_indicators_of_renal_function,.24.aspx 
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| Author Notes: | Can Can Xue, Li Qin Gao, Jing Cui, Chun Zhang, Dong Ning Chen, Ya Xing Wang, Jost B. Jonas |
| Summary: | Purpose: To investigate the prevalence of Gunn's dots (GDs) and associated systemic factors in adult Chinese. Methods: A cross-sectional study enrolling participants older than 45 years from a community-based study. Gunn's dots were evaluated using fundus photography, and associated systemic factors were analyzed. Patients with any retinal or optic neuropathy were excluded. Results: The study included 4,118 participants (mean age: 58.3 ± 9.9 years; male: 1,699/41.3%). Gunn's dots were found in 931 participants, with a prevalence of 22.6 ± 0.8% (95% confidence interval [CI]: 21.3-23.9). Systemic factors associated with a higher GD prevalence were younger age (odds ratio [OR]: 0.92; 95% CI: 0.91-0.93; P < 0.001), higher estimated glomerular filtration rate (eGFR) (OR: 1.01; 95% CI: 1.001-1.02; P = 0.022), and higher serum concentration of triglycerides (OR: 1.08; 95% CI: 1.004-1.16; P = 0.040). The GD prevalence was 3.5 (OR = 3.46; 95% CI: 1.06-11.35) and 4.4 (OR = 4.37; 95% CI: 1.27-15.09) times greater for participants with an eGFR of ≥90 mL/minute/1.73 m2 and an eGFR of ≥100 mL/minute/1.73 m2, respectively, as compared with participants with an eGFR of <60 mL/minute/1.73 m2. Conclusion: The GD prevalence (mean: 22.6%) was associated with younger age, higher eGFR, and higher serum triglyceride concentrations. The presence of GDs may serve as indicators of healthy renal function. |
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| Item Description: | Gesehen am 02.04.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1539-2864 |
| DOI: | 10.1097/IAE.0000000000003354 |