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CpG-biomarkers in tumor tissue and prediction models for the survival of colorectal cancer: A systematic review and external validation study

The research aimed to identify previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis and validate them in a large external cohort. A systematic search was conducted, analyzing 298 unique CpGs and 12 CpG-based prognostic models fr...

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Main Authors: Yuan, Tanwei (Author) , Edelmann, Dominic (Author) , Kather, Jakob Nikolas (Author) , Fan, Ziwen (Author) , Tagscherer, Katrin (Author) , Roth, Wilfried (Author) , Bewerunge-Hudler, Melanie (Author) , Brobeil, Alexander (Author) , Kloor, Matthias (Author) , Bläker, Hendrik (Author) , Burwinkel, Barbara (Author) , Brenner, Hermann (Author) , Hoffmeister, Michael (Author)
Format: Article (Journal)
Language:English
Published: January 2024
In: Critical reviews in oncology, hematology
Year: 2024, Volume: 193, Pages: 1-10
ISSN:1879-0461
DOI:10.1016/j.critrevonc.2023.104199
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.critrevonc.2023.104199
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1040842823002871?via%3Dihub
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Author Notes:Tanwei Yuan, Dominic Edelmann, Jakob N. Kather, Ziwen Fan, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Alexander Brobeil, Matthias Kloor, Hendrik Blaeker, Barbara Burwinkel, Hermann Brenner, Michael Hoffmeister
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Summary:The research aimed to identify previously published CpG-methylation-based prognostic biomarkers and prediction models for colorectal cancer (CRC) prognosis and validate them in a large external cohort. A systematic search was conducted, analyzing 298 unique CpGs and 12 CpG-based prognostic models from 28 studies. After adjustment for clinical variables, 48 CpGs and five prognostic models were confirmed to be associated with survival. However, the discrimination ability of the models was insufficient, with area under the receiver operating characteristic curves ranging from 0.53 to 0.62. Calibration accuracy was mostly poor, and no significant added prognostic value beyond traditional clinical variables was observed. All prognostic models were rated at high risk of bias. While a fraction of CpGs showed potential clinical utility and generalizability, the CpGbased prognostic models performed poorly and lacked clinical relevance.
Item Description:Online verfügbar: 11. November 2023
Gesehen am 08.04.2024
Physical Description:Online Resource
ISSN:1879-0461
DOI:10.1016/j.critrevonc.2023.104199

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