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Consequences of amyloid-β deficiency for the liver

The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advances in anti-Aβ therapies for Alzheimer's disease (AD). Her...

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Main Authors: Buniatian, Gayane (Author) , Schwinghammer, Ute (Author) , Tremmel, Roman (Author) , Cynis, Holger (Author) , Weiss, Thomas S. (Author) , Weiskirchen, Ralf (Author) , Lauschke, Volker Martin (Author) , Youhanna, Sonia (Author) , Ramos, Isbaal (Author) , Valcarcel, Maria (Author) , Seferyan, Torgom (Author) , Rahfeld, Jens-Ulrich (Author) , Rieckmann, Vera (Author) , Klein, Kathrin (Author) , Buadze, Marine (Author) , Weber, Victoria (Author) , Kolak, Valentina (Author) , Gebhardt, Rolf (Author) , Friedman, Scott L. (Author) , Müller, Ulrike C. (Author) , Schwab, Matthias (Author) , Danielyan, Lusine (Author)
Format: Article (Journal)
Language:English
Published: 15 May 2024
In: Advanced science
Year: 2024, Volume: 11, Issue: 18, Pages: 1-14
ISSN:2198-3844
DOI:10.1002/advs.202307734
Online Access:Resolving-System, kostenfrei: https://doi.org/10.1002/advs.202307734
Resolving-System, kostenfrei: https://doi.org/10.25673/117311
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Author Notes:Gayane Hrachia Buniatian, Ute Schwinghammer, Roman Tremmel, Holger Cynis, Thomas S. Weiss, Ralf Weiskirchen, Volker M. Lauschke, Sonia Youhanna, Isbaal Ramos, Maria Valcarcel, Torgom Seferyan, Jens-Ulrich Rahfeld, Vera Rieckmann, Kathrin Klein, Marine Buadze, Victoria Weber, Valentina Kolak, Rolf Gebhardt, Scott L. Friedman, Ulrike C. Müller, Matthias Schwab, and Lusine Danielyan
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Summary:The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of Aβ deficiency in the liver. This is especially relevant in view of recent advances in anti-Aβ therapies for Alzheimer's disease (AD). Here, it is shown that partial hepatic loss of Aβ in transgenic AD mice immunized with Aβ antibody 3D6 and its absence in amyloid precursor protein (APP) knockout mice (APP-KO), as well as in human liver spheroids with APP knockdown upregulates classical hallmarks of fibrosis, smooth muscle alpha-actin, and collagen type I. Aβ absence in APP-KO and deficiency in immunized mice lead to strong activation of transforming growth factor-β (TGFβ), alpha secretases, NOTCH pathway, inflammation, decreased permeability of liver sinusoids, and epithelial-mesenchymal transition. Inversely, increased systemic and intrahepatic levels of Aβ42 in transgenic AD mice and neprilysin inhibitor LBQ657-treated wild-type mice protect the liver against carbon tetrachloride (CCl4)-induced injury. Transcriptomic analysis of CCl4-treated transgenic AD mouse livers uncovers the regulatory effects of Aβ42 on mitochondrial function, lipid metabolism, and its onco-suppressive effects accompanied by reduced synthesis of extracellular matrix proteins. Combined, these data reveal Aβ as an indispensable regulator of cell–cell interactions in healthy liver and a powerful protector against liver fibrosis.
Item Description:Veröffentlicht: 02. März 2024
Physical Description:Online Resource
ISSN:2198-3844
DOI:10.1002/advs.202307734

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