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Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage

Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepw...

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Main Authors: Ho, Kim Hoa (Author) , Candat, Adrien (Author) , Scarpetta, Valentina (Author) , Faucourt, Marion (Author) , Weill, Solene (Author) , Salio, Chiara (Author) , D’Este, Elisa (Author) , Meschkat, Martin (Author) , Wurm, Christian A. (Author) , Kneussel, Matthias (Author) , Janke, Carsten (Author) , Magiera, Maria M. (Author) , Genovesio, Auguste (Author) , Meunier, Alice (Author) , Sassoè-Pognetto, Marco (Author) , Brill, Monika S. (Author) , Spassky, Nathalie (Author) , Patrizi, Annarita (Author)
Format: Article (Journal)
Language:English
Published: 4 December 2023
In: Developmental cell
Year: 2023, Volume: 58, Issue: 23, Pages: 2641-2651, e1-e6
ISSN:1878-1551
DOI:10.1016/j.devcel.2023.10.003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.devcel.2023.10.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1534580723005233
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Author Notes:Kim Hoa Ho, Adrien Candat, Valentina Scarpetta, Marion Faucourt, Solene Weill, Chiara Salio, Elisa D’Este, Martin Meschkat, Christian A. Wurm, Matthias Kneussel, Carsten Janke, Maria M. Magiera, Auguste Genovesio, Alice Meunier, Marco Sassoè-Pognetto, Monika S. Brill, Nathalie Spassky, and Annarita Patrizi
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Summary:Choroid plexuses (ChPs) produce cerebrospinal fluid and sense non-cell-autonomous stimuli to control the homeostasis of the central nervous system. They are mainly composed of epithelial multiciliated cells, whose development and function are still controversial. We have thus characterized the stepwise order of mammalian ChP epithelia cilia formation using a combination of super-resolution-microscopy approaches and mouse genetics. We show that ChP ciliated cells are built embryonically on a treadmill of spatiotemporally regulated events, starting with atypical centriole amplification and ending with the construction of nodal-like 9+0 cilia, characterized by both primary and motile features. ChP cilia undergo axoneme resorption at early postnatal stages through a microtubule destabilization process controlled by the microtubule-severing enzyme spastin and mitigated by polyglutamylation levels. Notably, this phenotype is preserved in humans, suggesting a conserved ciliary resorption mechanism in mammals.
Item Description:Online verfügbar 26 October 2023, Version des Artikels 4 December 2023
Gesehen am 12.04.2024
Physical Description:Online Resource
ISSN:1878-1551
DOI:10.1016/j.devcel.2023.10.003

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