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Exploring the efficacy of dialectical behaviour therapy and methylphenidate on emotional comorbid symptoms in adults with attention Deficit/Hyperactivity disorder: Results of the COMPAS multicentre randomised controlled trial

This study evaluated the efficacy of dialectical behaviour group therapy (GPT) vs. individual clinical management (CM) and methylphenidate (MPH) vs. placebo (PLB) on emotional symptoms in adults with ADHD. This longitudinal multicentre RCT compared four groups (GPT+MPH, GPT+PLB, CM+MPH, and CM+PLB)...

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Main Authors: López-Pinar, Carlos (Author) , Selaskowski, Benjamin (Author) , Braun, Niclas (Author) , Fornés-Ferrer, Victoria (Author) , Euscher, Rebekka (Author) , Matthies, Swantje (Author) , Jans, Thomas (Author) , van Elst, Ludger Tebartz (Author) , Jacob, Christian (Author) , Huss, Michael (Author) , Sobanski, Esther (Author) , Retz, Wolfgang (Author) , Roesler, Michael (Author) , Retz-Junginger, Petra (Author) , Alm, Barbara (Author) , Kis, Bernhard (Author) , Abdel-Hamid, Mona (Author) , Colla, Michael (Author) , Berger, Mathias (Author) , Lux, Silke (Author) , Philipsen, Alexandra (Author)
Format: Article (Journal)
Language:English
Published: December 2023
In: Psychiatry research
Year: 2023, Volume: 330, Pages: 1-10
ISSN:1872-7123
DOI:10.1016/j.psychres.2023.115610
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.psychres.2023.115610
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165178123005607
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Author Notes:Carlos López-Pinar, Benjamin Selaskowski, Niclas Braun, Victoria Fornés-Ferrer, Rebekka Euscher, Swantje Matthies, Thomas Jans, Ludger Tebartz van Elst, Christian Jacob, Michael Huss, Esther Sobanski, Wolfgang Retz, Michael Roesler, Petra Retz-Junginger, Barbara Alm, Bernhard Kis, Mona Abdel-Hamid, Michael Colla, Mathias Berger, Silke Lux, Alexandra Philipsen
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Summary:This study evaluated the efficacy of dialectical behaviour group therapy (GPT) vs. individual clinical management (CM) and methylphenidate (MPH) vs. placebo (PLB) on emotional symptoms in adults with ADHD. This longitudinal multicentre RCT compared four groups (GPT+MPH, GPT+PLB, CM+MPH, and CM+PLB) over five assessment periods, from baseline to week 130. Emotional symptomatology was assessed using SCL-90-R subscales. Of the 433 randomised participants, 371 remained for final analysis. At week 13, the GPT+MPH group showed smaller reductions in anxiety symptoms than the CM groups, but the differences disappeared at subsequent assessments. Improvements in emotional symptom were significantly predicted by reductions in core ADHD symptoms in all groups except the GPT+MPH group. The unexpected lack of between-group differences may be explained by a "floor effect", different intervention settings (group vs. individual), and psychotherapy type. Multiple regression analyses suggest a more specific effect of combined interventions (GPT+MPH). Implications for clinical practice are discussed. Clinical trial registration: ISRCTN54096201 (Current Controlled Trials).
Item Description:Online verfügbar: 18. November 2023, Artikelversion: 21. November 2023
Gesehen am 16.04.2024
Physical Description:Online Resource
ISSN:1872-7123
DOI:10.1016/j.psychres.2023.115610

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