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Fatal hepatic necrosis after isoflurane anaesthesia

Several halogenated anaesthetic agents have been associated with hepatotoxicity. We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane. Although no anti...

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Bibliographic Details
Main Authors: Weitz, Jürgen (Author) , Kienle, Peter (Author) , Böhrer, Hubert (Author) , Hofmann, Walter J. (Author) , Theilmann, Lorenz (Author) , Otto, Gerd (Author)
Format: Article (Journal)
Language:English
Published: 1997
In: Anaesthesia
Year: 1997, Volume: 52, Issue: 9, Pages: 892-895
ISSN:1365-2044
DOI:10.1111/j.1365-2044.1997.187-az0319.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1365-2044.1997.187-az0319.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2044.1997.187-az0319.x
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Author Notes:J. Weitz, P. Kienle, H. Böhrer, W. Hofmann, L. Theilmann, G. Otto
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Summary:Several halogenated anaesthetic agents have been associated with hepatotoxicity. We report a case of fulminant, fatal hepatic necrosis after uneventful isoflurane anaesthesia in a patient without previous liver disease, who may have been sensitised by previous exposure to enflurane. Although no anti-trifluoroacetyl antibodies could be detected in the patient's serum, isoflurane hepatotoxicity seems very likely to be the reason for fulminant hepatic failure in this patient.
Item Description:Elektronische Reproduktion der Druck-Ausgabe 30. September 2008
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Physical Description:Online Resource
ISSN:1365-2044
DOI:10.1111/j.1365-2044.1997.187-az0319.x

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