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Triantennary GalNAc molecular imaging probes for monitoring hepatocyte function in a rat model of nonalcoholic steatohepatitis

Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early diagnosis of NASH is vital to detect disease before it becomes life-threatening, yet noninvasively differentiating NASH from simple steatosis...

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Main Authors: Mishra, Anurag (Author) , Castañeda, Tamara R. (Author) , Bader, Erik (Author) , Elshorst, Bettina (Author) , Cummings, Sheila (Author) , Scherer, Petra (Author) , Bangari, Dinesh S. (Author) , Loewe, Claudia (Author) , Schreuder, Herman (Author) , Pöverlein, Christoph (Author) , Helms, Mike (Author) , Jones, Seth (Author) , Zech, Gernot (Author) , Licher, Thomas (Author) , Wagner, Michael (Author) , Schudok, Manfred (Author) , de Hoop, Meltsje (Author) , Plowright, Alleyn T. (Author) , Atzrodt, Jens (Author) , Kannt, Aimo (Author) , Laitinen, Iina (Author) , Derdau, Volker (Author)
Format: Article (Journal)
Language:English
Published: December 16, 2020
In: Advanced science
Year: 2020, Volume: 7, Issue: 24, Pages: 1-9
ISSN:2198-3844
DOI:10.1002/advs.202002997
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/advs.202002997
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202002997
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Author Notes:Anurag Mishra, Tamara R. Castañeda, Erik Bader, Bettina Elshorst, Sheila Cummings, Petra Scherer, Dinesh S. Bangari, Claudia Loewe, Herman Schreuder, Christoph Pöverlein, Mike Helms, Seth Jones, Gernot Zech, Thomas Licher, Michael Wagner, Manfred Schudok, Meltsje de Hoop, Alleyn T. Plowright, Jens Atzrodt, Aimo Kannt, Iina Laitinen, and Volker Derdau
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Summary:Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early diagnosis of NASH is vital to detect disease before it becomes life-threatening, yet noninvasively differentiating NASH from simple steatosis is challenging. Herein, bifunctional probes have been developed that target the hepatocyte-specific asialoglycoprotein receptor (ASGPR), the expression of which decreases during NASH progression. The results show that the probes allow longitudinal, noninvasive monitoring of ASGPR levels by positron emission tomography in the newly developed rat model of NASH. The probes open new possibilities for research into early diagnosis of NASH and development of drugs to slow or reverse its progression.
Item Description:Online veröffentlicht: 9. November 2020
Gesehen am 03.05.2024
Physical Description:Online Resource
ISSN:2198-3844
DOI:10.1002/advs.202002997

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