Cover Image

Tumor-reactive T helper cells in the context of vaccination against glioma

With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action o...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhao, Binghao (Author) , Kilian, Michael (Author) , Bunse, Theresa (Author) , Platten, Michael (Author) , Bunse, Lukas (Author)
Format: Article (Journal)
Language:English
Published: 13 November 2023
In: Cancer cell
Year: 2023, Volume: 41, Issue: 11, Pages: 1829-1834
ISSN:1878-3686
DOI:10.1016/j.ccell.2023.09.013
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccell.2023.09.013
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S153561082300329X
Get full text
Author Notes:Binghao Zhao, Michael Kilian, Theresa Bunse, Michael Platten and Lukas Bunse
Description
Summary:With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of THCs as precision antitumor agonists. Here, we discuss the specific cellular mechanisms of THC functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting THCs.
Item Description:Online verfügbar: 19. Oktober 2023, Artikelversion: 13. November 2023
Gesehen am 07.05.2024
Physical Description:Online Resource
ISSN:1878-3686
DOI:10.1016/j.ccell.2023.09.013

Similar Items