Tumor-reactive T helper cells in the context of vaccination against glioma
With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action o...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 November 2023
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| In: |
Cancer cell
Year: 2023, Jahrgang: 41, Heft: 11, Pages: 1829-1834 |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2023.09.013 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ccell.2023.09.013 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S153561082300329X 
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| Verfasserangaben: | Binghao Zhao, Michael Kilian, Theresa Bunse, Michael Platten and Lukas Bunse |
| Zusammenfassung: | With the advances in immunogenomics, the majority of tumor-specific antigens were found to be recognized by T helper cells (THCs). This observation led to the development of long epitope vaccines in various cancers. Mechanistically, we are still gaining a deeper understanding of the mode of action of THCs as precision antitumor agonists. Here, we discuss the specific cellular mechanisms of THC functions in glioma immunology and contextualize current advances in anti-glioma vaccination exploiting THCs. |
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| Beschreibung: | Online verfügbar: 19. Oktober 2023, Artikelversion: 13. November 2023 Gesehen am 07.05.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1878-3686 |
| DOI: | 10.1016/j.ccell.2023.09.013 |