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Prediction of dementia of Alzheimer type by different types of subjective cognitive decline

Introduction Subjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT). Methods We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all-cause dementia, and DAT in different SCD types (decline i...

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Hauptverfasser: Jessen, Frank (VerfasserIn) , Kleineidam, Luca (VerfasserIn) , Wolfsgruber, Steffen (VerfasserIn) , Bickel, Horst (VerfasserIn) , Brettschneider, Christian (VerfasserIn) , Fuchs, Angela (VerfasserIn) , Kaduszkiewicz, Hanna (VerfasserIn) , König, Hans-Helmut (VerfasserIn) , Mallon, Tina (VerfasserIn) , Mamone, Silke (VerfasserIn) , Pabst, Alexander (VerfasserIn) , Pentzek, Michael (VerfasserIn) , Roehr, Susanne (VerfasserIn) , Weeg, Dagmar (VerfasserIn) , Jochen, Werle (VerfasserIn) , Weyerer, Siegfried (VerfasserIn) , Wiese, Birgitt (VerfasserIn) , Maier, Wolfgang (VerfasserIn) , Scherer, Martin (VerfasserIn) , Riedel-Heller, Steffi (VerfasserIn) , Wagner, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 2020
In: Alzheimer's and dementia
Year: 2020, Jahrgang: 16, Heft: 12, Pages: 1745-1749
ISSN:1552-5279
DOI:10.1002/alz.12163
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/alz.12163
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/alz.12163
Volltext
Verfasserangaben:Frank Jessen, Luca Kleineidam, Steffen Wolfsgruber, Horst Bickel, Christian Brettschneider, Angela Fuchs, Hanna Kaduszkiewicz, Hans-Helmut König, Tina Mallon, Silke Mamone, Alexander Pabst, Michael Pentzek, Susanne Roehr, Dagmar Weeg, Werle Jochen, Siegfried Weyerer, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Steffi Riedel-Heller, Michael Wagner
Beschreibung
Zusammenfassung:Introduction Subjective cognitive decline (SCD) is a risk condition for dementia, including dementia of Alzheimer type (DAT). Methods We report sensitivity, specificity, positive and negative predictive values (PPV, NPV) for conversion to all-cause dementia, and DAT in different SCD types (decline in memory, assocated worries, longitudinal consitency, of the AgeCoDe study (n = 2.402, 12 years follow-up). Results 82.7% of those converting to any dementia and 84.4% of those converting with DAT at follow-up, reported memory decline and fulfilled criteria of SCD at least at one time point before. SCD with worries at two consecutive time points showed a specificity of 92.2% for any dementia and also for DAT as well as a PPV of 44.3% for any dementia and of 36.9% for DAT at follow-up at the expense of low sensitivity. Discussion Different SCD subtypes were either sensitive or specific for future all-cause dementia and DAT in cognitively unimpaired individuals. Modest PPV of the most specific SCD subtypes were achieved in this low prevalence population.
Beschreibung:Online veröffentlicht: 2. November 2020
Gesehen am 23.05.2024
Beschreibung:Online Resource
ISSN:1552-5279
DOI:10.1002/alz.12163

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