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Plasma interferon-γ-inducible protein 10 (IP-10) levels correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis

With 1.5 million deaths worldwide in 2018, tuberculosis (TB) remains a major global public health problem. While pulmonary TB (PTB) is the most common manifestation, the proportion of extrapulmonary TB (EPTB) is increasing in low-burden countries. EPTB is a heterogeneous disease entity posing diagno...

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Main Authors: Suárez, Isabelle (Author) , Rohr, Samuel (Author) , Stecher, Melanie (Author) , Lehmann, Clara (Author) , Winter, Sandra (Author) , Jung, Norma (Author) , Priesner, Vanessa (Author) , Berger, Melanie (Author) , Wyen, Christoph (Author) , Augustin, Max (Author) , Malin, Jakob J. (Author) , Fischer, Julia (Author) , Horn, Carola (Author) , Neuhann, Florian (Author) , Püsken, Michael (Author) , Plum, Georg (Author) , Fätkenheuer, Gerd (Author) , Rybniker, Jan (Author)
Format: Article (Journal)
Language:English
Published: June 2021
In: Infection
Year: 2021, Volume: 49, Issue: 3, Pages: 437-445
ISSN:1439-0973
DOI:10.1007/s15010-020-01541-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s15010-020-01541-1
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Author Notes:Isabelle Suárez, Samuel Rohr, Melanie Stecher, Clara Lehmann, Sandra Winter, Norma Jung, Vanessa Priesner, Melanie Berger, Christoph Wyen, Max Augustin, Jakob J. Malin, Julia Fischer, Carola Horn, Florian Neuhann, Michael Püsken, Georg Plum, Gerd Fätkenheuer, Jan Rybniker
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Summary:With 1.5 million deaths worldwide in 2018, tuberculosis (TB) remains a major global public health problem. While pulmonary TB (PTB) is the most common manifestation, the proportion of extrapulmonary TB (EPTB) is increasing in low-burden countries. EPTB is a heterogeneous disease entity posing diagnostic and management challenges due to the lack of reliable biomarkers. In this study, we prospectively evaluated clinical data and treatment response which were correlated with different biomarkers.
Item Description:Gesehen am 23.05.2024
Online veröffentlicht: 2. November 2020
Physical Description:Online Resource
ISSN:1439-0973
DOI:10.1007/s15010-020-01541-1

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