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High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer: laboratory-bladder cancer

Introduction - Molecular markers associated with breast cancer are assumed to be associated with outcome in non-muscle-invasive bladder cancer (NMIBC). - Materials and methods - We retrospectively investigated the association of the mRNA expression of estrogen receptor 1 (ESR1) and 2 (ESR2), progest...

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Main Authors: Sikic, Danijel (Author) , Eckstein, Markus (Author) , Weyerer, Veronika (Author) , Kubon, Jennifer (Author) , Breyer, Johannes (Author) , Roghmann, Florian (Author) , Kunath, Frank (Author) , Keck, Bastian (Author) , Erben, Philipp (Author) , Hartmann, Arndt (Author) , Wirtz, Ralph M. (Author) , Wullich, Bernd (Author) , Taubert, Helge (Author) , Wach, Sven (Author)
Format: Article (Journal)
Language:English
Published: February 2022
In: Urologic oncology
Year: 2022, Volume: 40, Issue: 2, Pages: 63.e9-63.e18
ISSN:1873-2496
DOI:10.1016/j.urolonc.2021.06.021
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.urolonc.2021.06.021
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1078143921002970
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Author Notes:Danijel Sikic, Markus Eckstein, Veronika Weyerer, Jennifer Kubon, Johannes Breyer, Florian Roghmann, Frank Kunath, Bastian Keck, Philipp Erben, Arndt Hartmann, Ralph M. Wirtz, Bernd Wullich, Helge Taubert, Sven Wach
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Summary:Introduction - Molecular markers associated with breast cancer are assumed to be associated with outcome in non-muscle-invasive bladder cancer (NMIBC). - Materials and methods - We retrospectively investigated the association of the mRNA expression of estrogen receptor 1 (ESR1) and 2 (ESR2), progesterone receptor (PGR), MKI67, and HER2 (ERBB2) with recurrence-free (RFS), cancer-specific (CSS), and overall survival (OS) in 80 patients with stage T1 NMIBC. - Results - High expression of ESR2 (P=0.003), ERBB2 (P < 0.001), and MKI67 (P=0.029) was associated with shorter RFS. Only high ERBB2 was an independent prognostic factor for reduced RFS (HR=2.98; P=0.009). When sub stratifying the cohort, high ESR2 was associated with reduced RFS (P < 0.001), CSS (P=0.037) and OS (P=0.006) in patients without instillation therapy. High ESR2 was associated with reduced CSS (P=0.018) and OS (P=0.029) in females and with shorter RFS in both sexes (males: P=0.035; females: P=0.010). Patients with high ERBB2 showed reduced CSS (P=0.011) and OS (P=0.042) in females and reduced CSS (P=0.012) in those without instillation, while RFS was significantly reduced irrespective of sex or instillation. - Conclusion - High mRNA expression of ERBB2 is an independent predictor of reduced RFS in patients with stage T1 NMIBC. High ERBB2 and ESR2 are associated with reduced outcomes, especially in females and patients without instillation therapy.
Item Description:Online verfügbar: 28. Juli 2021, Artikelversion: 29. Januar 2022
Gesehen am 27.05.2024
Physical Description:Online Resource
ISSN:1873-2496
DOI:10.1016/j.urolonc.2021.06.021

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