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Assessing long-term, vestibulotoxic side effects after gentamicin therapy in neonatal sepsis or infection using video head impulse test

Question: Does gentamicin therapy in children with neonatal sepsis or infection lead to persistent vestibulotoxicity? Findings: In a single-center, prospective cross-sectional study video head impulse test (VHIT) was performed to evaluate vestibular function in 23 children aged 3-7 years at least th...

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Bibliographic Details
Main Authors: Zaubitzer, Lena (Author) , Kotzur, Anja (Author) , Hegemann, Stefan (Author) , Rotter, Nicole (Author) , Schell, Angela (Author)
Format: Article (Journal)
Language:English
Published: 26 February 2024
In: Frontiers in Pediatrics
Year: 2024, Volume: 12, Pages: 1-17
ISSN:2296-2360
DOI:10.3389/fped.2024.1366074
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fped.2024.1366074
Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fped.2024.1366074
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Author Notes:Lena Zaubitzer, Anja Kotzur, Stefan Hegemann, Nicole Rotter and Angela Schell
Description
Summary:Question: Does gentamicin therapy in children with neonatal sepsis or infection lead to persistent vestibulotoxicity? Findings: In a single-center, prospective cross-sectional study video head impulse test (VHIT) was performed to evaluate vestibular function in 23 children aged 3-7 years at least three years after intravenous gentamicin therapy for neonatal sepsis or infection.Although eleven children showed abnormal results in vestibular testing, they did not present with a clinically significant vestibular hypofunction or delayed motoric development.VHIT can serve as a sensitive investigation method for the screening of posttherapeutic vestibulotoxic side effects after gentamicin therapy in children.
Item Description:Gesehen am 28.05.2024
Physical Description:Online Resource
ISSN:2296-2360
DOI:10.3389/fped.2024.1366074

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