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Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons

We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic products. This post-Groebke-Blackburn-Bienaymé (GBB) reaction introduces a new class of functionalized isocyanides. Tran...

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Main Authors: Aghaie, Kimia (Author) , Amiri, Kamran (Author) , Rezaei-Gohar, Mohammad (Author) , Rominger, Frank (Author) , Dar’in, Dmitry (Author) , Sapegin, Alexander (Author) , Balalaie, Saeed (Author)
Format: Article (Journal)
Language:English
Published: 07 Feb 2024
In: Chemical communications
Year: 2024, Volume: 60, Issue: 19, Pages: 2661-2664
ISSN:1364-548X
DOI:10.1039/D3CC05724K
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/D3CC05724K
Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2024/cc/d3cc05724k
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Author Notes:Kimia Aghaie, Kamran Amiri, Mohammad Rezaei-Gohar, Frank Rominger, Dmitry Dar’in, Alexander Sapegin and Saeed Balalaie
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Summary:We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic products. This post-Groebke-Blackburn-Bienaymé (GBB) reaction introduces a new class of functionalized isocyanides. Transition-metal-free cyclization, broad substrate scope, and high atom economy were some features of the present protocol.
Item Description:Zuerst veröffentlicht: 7. Februar 2024
Gesehen am 06.06.2024
Physical Description:Online Resource
ISSN:1364-548X
DOI:10.1039/D3CC05724K

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