Transition-metal-free intramolecular double hydrofunctionalization of alkyne to access 6/7/5-fused heterocyclic skeletons
We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic products. This post-Groebke-Blackburn-Bienaymé (GBB) reaction introduces a new class of functionalized isocyanides. Tran...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
07 Feb 2024
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| In: |
Chemical communications
Year: 2024, Jahrgang: 60, Heft: 19, Pages: 2661-2664 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/D3CC05724K |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1039/D3CC05724K Verlag, lizenzpflichtig, Volltext: https://pubs.rsc.org/en/content/articlelanding/2024/cc/d3cc05724k 
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| Verfasserangaben: | Kimia Aghaie, Kamran Amiri, Mohammad Rezaei-Gohar, Frank Rominger, Dmitry Dar’in, Alexander Sapegin and Saeed Balalaie |
| Zusammenfassung: | We describe a novel intramolecular double hydrofunctionalization cyclization of alkyne with nitrogen and oxygen nucleophilic groups to construct valuable 6/7/5-fused heterocyclic products. This post-Groebke-Blackburn-Bienaymé (GBB) reaction introduces a new class of functionalized isocyanides. Transition-metal-free cyclization, broad substrate scope, and high atom economy were some features of the present protocol. |
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| Beschreibung: | Zuerst veröffentlicht: 7. Februar 2024 Gesehen am 06.06.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1364-548X |
| DOI: | 10.1039/D3CC05724K |