IL-1β knockout increases the intestinal abundancy of Akkermansia muciniphila
Abstract The proinflammatory cytokine interleukin-1β (IL-1β) is known to be upregulated in patients suffering from metabolic syndrome. IL-1β contributes to insulin resistance in obesity and type 2 diabetes, yet its influence on the intestinal microbiome is incompletely understood. The data presented...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1 December 2023
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| In: |
Beneficial microbes
Year: 2023, Volume: 14, Issue: 4, Pages: 361-370 |
| ISSN: | 1876-2891 |
| DOI: | 10.1163/18762891-20220042 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1163/18762891-20220042 Verlag, kostenfrei, Volltext: https://brill.com/view/journals/bm/14/4/article-p361_5.xml 
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| Author Notes: | M. Bechberger, T. Eigenbrod, S. Boutin, K. Heeg and K.A. Bode |
| Summary: | Abstract The proinflammatory cytokine interleukin-1β (IL-1β) is known to be upregulated in patients suffering from metabolic syndrome. IL-1β contributes to insulin resistance in obesity and type 2 diabetes, yet its influence on the intestinal microbiome is incompletely understood. The data presented here demonstrate that mice genetically deficient in IL-1β show a specific alteration of intestinal colonisation of a small group of bacteria. Especially Akkermansia muciniphila, a bacterium reported to be inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation, showed increased colonisation in IL-1β knockout mice. In comparative microarray analysis from mucus scrapings of the colon mucosa of IL-1β knockout and wildtype mice, angiogenin 4 mRNA was strongly reduced in IL-1β knockout animals. Since the presence of angiogenin 4 in the culture medium showed a significant growth inhibition on A. muciniphila which was not detectable for other bacteria tested, IL-1β induced expression of angiogenin 4 is a strong candidate to be responsible for the IL-1β induced suppression of A. muciniphila colonisation. Thus, the data presented here indicate that IL-1β might be the lacking link between inflammation and suppression of A. muciniphila abundance as observed in a variety of chronic inflammatory disorders. |
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| Item Description: | Online veröffentlicht: 1. September 2023 Gesehen am 06.06.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1876-2891 |
| DOI: | 10.1163/18762891-20220042 |