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Vascularized 3D human skin models in the forefront of dermatological research

In vitro engineered skin models are emerging as an alternative platform to reduce and replace animal testing in dermatological research. Despite the progress made in recent years, considerable challenges still exist for the inclusion of diverse cell types within skin models. Blood vessels, in partic...

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Main Authors: Rimal, Rahul (Author) , Muduli, Saradaprasan (Author) , Desai, Prachi (Author) , Marquez, Andrea Bonnin (Author) , Möller, Martin (Author) , Platzman, Ilia (Author) , Spatz, Joachim P. (Author) , Singh, Smriti (Author)
Format: Article (Journal)
Language:English
Published: April 5, 2024
In: Advanced healthcare materials
Year: 2024, Volume: 13, Issue: 9, Pages: 1-22
ISSN:2192-2659
DOI:10.1002/adhm.202303351
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/adhm.202303351
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202303351
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Author Notes:Rahul Rimal, Saradaprasan Muduli, Prachi Desai, Andrea Bonnin Marquez, Martin Möller, Ilia Platzman, Joachim Spatz, and Smriti Singh
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Summary:In vitro engineered skin models are emerging as an alternative platform to reduce and replace animal testing in dermatological research. Despite the progress made in recent years, considerable challenges still exist for the inclusion of diverse cell types within skin models. Blood vessels, in particular, are essential in maintaining tissue homeostasis and are one of many primary contributors to skin disease inception and progression. Substantial efforts in the past have allowed the successful fabrication of vascularized skin models that are currently utilized for disease modeling and drugs/cosmetics testing. This review first discusses the need for vascularization within tissue-engineered skin models, highlighting their role in skin grafting and disease pathophysiology. Second, the review spotlights the milestones and recent progress in the fabrication and utilization of vascularized skin models. Additionally, advances including the use of bioreactors, organ-on-a-chip devices, and organoid systems are briefly explored. Finally, the challenges and future outlook for vascularized skin models are addressed.
Item Description:Zuerst veröffentlicht: 26. Januar 2024
Gesehen am 11.06.2024
Physical Description:Online Resource
ISSN:2192-2659
DOI:10.1002/adhm.202303351

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