Cover Image

Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa

A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutation...

Full description

Saved in:
Bibliographic Details
Main Authors: Haas, Walter (Author) , Schilke, Kathrin (Author) , Brand, J. (Author) , Amthor, Beate (Author) , Weyer, K. (Author) , Fourie, P. B. (Author) , Bretzel, Gisela (Author) , Sticht-Groh, Veronica (Author) , Bremer, Hans J. (Author)
Format: Article (Journal)
Language:English
Published: 1 July 1997
In: Antimicrobial agents and chemotherapy
Year: 1997, Volume: 41, Issue: 7, Pages: 1601-1603
ISSN:1098-6596
DOI:10.1128/aac.41.7.1601
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/aac.41.7.1601
Verlag, lizenzpflichtig, Volltext: https://journals.asm.org/doi/10.1128/aac.41.7.1601
Get full text
Author Notes:WH Haas, K Schilke, J Brand, B Amthor, K Weyer, PB Fourie, G Bretzel, V Sticht-Groh, HJ Bremer
Description
Summary:A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.
Item Description:Gesehen am 20.06.2024
Physical Description:Online Resource
ISSN:1098-6596
DOI:10.1128/aac.41.7.1601

Similar Items