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Hypoxia sensing and responses in Parkinson’s disease

Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD,...

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Main Authors: Burtscher, Johannes (Author) , Duderstadt, Yves (Author) , Gatterer, Hannes (Author) , Burtscher, Martin (Author) , Vozdek, Roman (Author) , Millet, Grégoire (Author) , Hicks, Andrew A. (Author) , Ehrenreich, Hannelore (Author) , Kopp, Martin (Author)
Format: Article (Journal)
Language:English
Published: 1 February 2024
In: International journal of molecular sciences
Year: 2024, Volume: 25, Issue: 3, Pages: 1-13
ISSN:1422-0067
DOI:10.3390/ijms25031759
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms25031759
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/25/3/1759
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Author Notes:Johannes Burtscher, Yves Duderstadt, Hannes Gatterer, Martin Burtscher, Roman Vozdek, Grégoire P. Millet, Andrew A. Hicks, Hannelore Ehrenreich and Martin Kopp
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Summary:Parkinson’s disease (PD) is associated with various deficits in sensing and responding to reductions in oxygen availability (hypoxia). Here we summarize the evidence pointing to a central role of hypoxia in PD, discuss the relation of hypoxia and oxygen dependence with pathological hallmarks of PD, including mitochondrial dysfunction, dopaminergic vulnerability, and alpha-synuclein-related pathology, and highlight the link with cellular and systemic oxygen sensing. We describe cases suggesting that hypoxia may trigger Parkinsonian symptoms but also emphasize that the endogenous systems that protect from hypoxia can be harnessed to protect from PD. Finally, we provide examples of preclinical and clinical research substantiating this potential.
Item Description:Gesehen am 21.06.2024
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms25031759

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