A sialic acid analogue acting as a receptor determinant for binding but not for infection by influenza C virus
We describe a synthetic sialic acid analogue, 9-thioacetamido-N-acetylneuraminic acid (9-thioacetamido-Neu5Ac), which is recognized by the receptor-binding activity of influenza C virus, but is resistant to the receptor-destroying enzyme (acetylesterase) of this virus. Following transfer of the anal...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 24, 1993
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| In: |
FEBS letters
Year: 1993, Volume: 323, Issue: 1/2, Pages: 96-98 |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/0014-5793(93)81456-A |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0014-5793(93)81456-A Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2893%2981456-A 
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| Author Notes: | Reinhard Brossmer, Rainer Isecke, Georg Herrler |
| Summary: | We describe a synthetic sialic acid analogue, 9-thioacetamido-N-acetylneuraminic acid (9-thioacetamido-Neu5Ac), which is recognized by the receptor-binding activity of influenza C virus, but is resistant to the receptor-destroying enzyme (acetylesterase) of this virus. Following transfer of the analogue to the surface of receptor-negative cells, influenza C virus is able to attach to these cells, but is unable to infect the cells. This result suggests that inactivation of virus receptors by the receptor-destroying enzyme is essential for initiation of infection. Because of their unique properties such analogues promise to be powerful chemotherapeutic agents. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 14. November 2001 Gesehen am 24.06.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1873-3468 |
| DOI: | 10.1016/0014-5793(93)81456-A |