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Mapping Research Domain Criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis

This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnoso...

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Main Authors: Förstner, Bernd Rainer (Author) , Tschorn, Mira (Author) , Reinoso-Schiller, Nicolas (Author) , Maričić, Lea Mascarell (Author) , Röcher, Erik (Author) , Kalman, Janos L. (Author) , Stroth, Sanna (Author) , Mayer, Annalina V. (Author) , Schwarz, Kristina (Author) , Kaiser, Anna (Author) , Pfennig, Andrea (Author) , Manook, André (Author) , Ising, Marcus (Author) , Heinig, Ingmar (Author) , Pittig, Andre (Author) , Heinz, Andreas (Author) , Mathiak, Klaus (Author) , Schulze, Thomas G. (Author) , Schneider, Frank (Author) , Kamp-Becker, Inge (Author) , Meyer-Lindenberg, Andreas (Author) , Padberg, Frank (Author) , Banaschewski, Tobias (Author) , Bauer, Michael (Author) , Rupprecht, Rainer (Author) , Wittchen, Hans-Ulrich (Author) , Rapp, Michael A. (Author)
Format: Article (Journal)
Language:English
Published: April 2023
In: European archives of psychiatry and clinical neuroscience
Year: 2023, Volume: 273, Issue: 3, Pages: 527-539
ISSN:1433-8491
DOI:10.1007/s00406-022-01440-6
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00406-022-01440-6
Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00406-022-01440-6
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Author Notes:Bernd R. Förstner, Mira Tschorn, Nicolas Reinoso-Schiller, Lea Mascarell Maričić, Erik Röcher, Janos L. Kalman, Sanna Stroth, Annalina V. Mayer, Kristina Schwarz, Anna Kaiser, Andrea Pfennig, André Manook, Marcus Ising, Ingmar Heinig, Andre Pittig, Andreas Heinz, Klaus Mathiak, Thomas G. Schulze, Frank Schneider, Inge Kamp-Becker, Andreas Meyer-Lindenberg, Frank Padberg, Tobias Banaschewski, Michael Bauer, Rainer Rupprecht, Hans-Ulrich Wittchen, Michael A. Rapp
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Summary:This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix.
Item Description:Online veröffentlicht: 01. Juli 2022
Gesehen am 24.06.2024
Physical Description:Online Resource
ISSN:1433-8491
DOI:10.1007/s00406-022-01440-6

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