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Do we need MRI in all biopsy naïve patients?: a multicenter cohort analysis

Purpose: The combined approach (CB) of magnetic resonance imaging (MRI)-guided biopsy (TB) and systematic biopsy (SB) is strongly recommended based on numerous studies in biopsy naïve men with suspicion of clinically significant prostate cancer (csPCA). However, the unbalanced accessibility of MRI,...

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Main Authors: Krausewitz, Philipp (Author) , Borkowetz, Angelika (Author) , Ortner, Gernot (Author) , Kornienko, Kira (Author) , Wenzel, Mike (Author) , Westhoff, Niklas Christian (Author)
Format: Article (Journal)
Language:English
Published: 07 February 2024
In: World journal of urology
Year: 2024, Volume: 42, Pages: 1-7
ISSN:1433-8726
DOI:10.1007/s00345-024-04780-1
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00345-024-04780-1
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Author Notes:Philipp Krausewitz, Angelika Borkowetz, Gernot Ortner, Kira Kornienko, Mike Wenzel, Niklas Westhoff, GESRU Academics Prostate Cancer Group
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Summary:Purpose: The combined approach (CB) of magnetic resonance imaging (MRI)-guided biopsy (TB) and systematic biopsy (SB) is strongly recommended based on numerous studies in biopsy naïve men with suspicion of clinically significant prostate cancer (csPCA). However, the unbalanced accessibility of MRI, challenges related to reimbursement and the scarcity of specialized medical practitioners continue to impede a widespread implementation. Therefore, our objective was to determine a subset of men that could undergo SB without an increased risk of underdiagnosis at reduced expenses. Methods: A multicenter analysis of 2714 men with confirmed PCA and suspicious MRI who underwent CB were enrolled. Cancer detection rates were compared between the different biopsy routes SB, TB and CB using McNemar paired test. Additionally, Gleason grade up- and down-grading was determined. Results: CB detected more csPCA than TB and SB (p < 0.001), irrespective of MRI findings or biopsy route (transperineal vs. transrectal). Thereby, single biopsy approaches misgraded > 50% of csPCA. TB showed higher diagnostic efficiency, defined as csPCA detection per biopsy core than CB and SB (p < 0.001). For patients with abnormal DRE and PSA levels > 12.5 ng/ml, PSAD > 0.35 ng/ml/cm3, or > 75 years, SB and CB showed similar csPCA detection rates. Conclusion: Conducting CB provides the highest level of diagnostic certainty and minimizes the risk of underdiagnosis in almost all biopsy-naive men. However, in patients with suspicious DRE and high PSA levels, PSAD, or advanced age solely using SB leads to similar csPCA detection rates. Thus, a reduced biopsy protocol may be considered for these men in case resources are limited.
Item Description:Gesehen am 25.06.2024
Physical Description:Online Resource
ISSN:1433-8726
DOI:10.1007/s00345-024-04780-1

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