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Patient-reported outcomes in advanced NSCLC before and during the COVID-19 pandemic: real-world data from the German prospective CRISP Registry (AIO-TRK-0315)

Patients with lung cancer under treatment have been associated with a high risk of COVID-19 infection and potentially worse outcome, but real-world data on patient-reported outcomes (PROs) are rare. We assess patients' characteristics and PROs before and during the COVID-19 pandemic in an advan...

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Main Authors: Sebastian, Martin (Author) , Eberhardt, Wilfried E. E. (Author) , Heyde, Eyck von der (Author) , Dörfel, Steffen (Author) , Wiegand, Jörg (Author) , Schiefer, Clemens (Author) , Losem, Christoph (Author) , Jänicke, Martina (Author) , Fleitz, Annette (Author) , Zacharias, Stefan (Author) , Kaiser-Osterhues, Anja (Author) , Hipper, Annette (Author) , Dietel, Corinna (Author) , Bleckmann, Annalen (Author) , Benkelmann, Robin (Author) , Boesche, Michael (Author) , Grah, Christian (Author) , Müller, Annette (Author) , Griesinger, Frank (Author) , Thomas, Michael (Author)
Format: Article (Journal)
Language:English
Published: 1 June 2024
In: International journal of cancer
Year: 2024, Volume: 154, Issue: 11, Pages: 1967-1978
ISSN:1097-0215
DOI:10.1002/ijc.34868
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ijc.34868
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.34868
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Author Notes:Martin Sebastian, Wilfried E. E. Eberhardt, Eyck von der Heyde, Steffen Dörfel, Jörg Wiegand, Clemens Schiefer, Christoph Losem, Martina Jänicke, Annette Fleitz, Stefan Zacharias, Anja Kaiser-Osterhues, Annette Hipper, Corinna Dietel, Annalen Bleckmann, Robin Benkelmann, Michael Boesche, Christian Grah, Annette Müller, Frank Griesinger, Michael Thomas, for the CRISP Registry Group
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Summary:Patients with lung cancer under treatment have been associated with a high risk of COVID-19 infection and potentially worse outcome, but real-world data on patient-reported outcomes (PROs) are rare. We assess patients' characteristics and PROs before and during the COVID-19 pandemic in an advanced non-small cell lung cancer (NSCLC) cohort in Germany. Patients with locally advanced or metastatic NSCLC from the prospective, multicentre, observational CRISP Registry (NCT02622581) were categorised as pre-pandemic (March 2019 to Feb 2020, n = 1621) and pandemic (March 2020 to Feb 2021, n = 1317). From baseline to month 15, patients' health-related quality of life (HRQoL) was assessed by FACT-L, anxiety and depression by PHQ-4. Association of pandemic status with time to deterioration (TTD) in QoL scales adjusted for potential covariates was estimated using Cox modelling. PROs were documented for 1166 patients (72%) in the pre-pandemic, 979 (74%) in the pandemic group. Almost 60% of patients were male, median age was 66 years, comorbidities occurred in 85%. Regarding HRQoL, mean-change-from-baseline plots hardly differed between both samples. Approximately 15%-21% of patients reported anxiety, about 19%-27% signs of depression. For the pandemic group, TTD was slightly, but statistically significantly, worse for the physical well-being-FACT-G subscale (HR 1.15 [95%CI 1.02-1.30]) and the anxiety-GAD-2 subscale (HR 1.14 [95%CI 1.01-1.29]). These prospectively collected real-world data provide valuable insights into PROs before and during the COVID-19 pandemic in advanced NSCLC. For the patients, the pandemic seemed to be less of a burden than the disease itself, as there was a considerable proportion of patients with anxiety and depression in both groups.
Item Description:Zuerst veröffentlicht: 08. Februar 2024
Gesehen am 26.06.2024
Physical Description:Online Resource
ISSN:1097-0215
DOI:10.1002/ijc.34868

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