Photoreactive CMP-sialic acids as substrates for α2,6-sialyltransferase
Chemo-enzymatic synthesis afforded a series of CMP-activated sialic acids carrying a photoreactive group at C-9 or C-5, and in part a radiolabel as well. They were found to be accepted by α2,6-sialyltransferase. - Differing amino group reactivity of novel 5,9-diamino sialic acid enabled us to attach...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
7 December 1995
|
| In: |
Bioorganic & medicinal chemistry letters
Year: 1995, Jahrgang: 5, Heft: 23, Pages: 2809-2814 |
| ISSN: | 1464-3405 |
| DOI: | 10.1016/0960-894X(95)00491-B |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0960-894X(95)00491-B Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/0960894X9500491B 
|
| Verfasserangaben: | Paraskevi Mirelis, Reinhard Brossmer |
| Zusammenfassung: | Chemo-enzymatic synthesis afforded a series of CMP-activated sialic acids carrying a photoreactive group at C-9 or C-5, and in part a radiolabel as well. They were found to be accepted by α2,6-sialyltransferase. - Differing amino group reactivity of novel 5,9-diamino sialic acid enabled us to attach sequentially a benzophenone photophore at C-9 and a radiolabel at C-5. |
|---|---|
| Beschreibung: | Elektronische Reproduktion der Druck-Ausgabe 29. März 2000 Gesehen am 27.06.2024 |
| Beschreibung: | Online Resource |
| ISSN: | 1464-3405 |
| DOI: | 10.1016/0960-894X(95)00491-B |