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A comprehensive histomolecular characterization of meningioangiomatosis: further evidence for a precursor neoplastic lesion

Meningioangiomatosis (MAM) remains a poorly understood lesion responsible for epileptic disease. In the past, MAM was primarily described in the context of neurofibromatosis type 2 before being mainly reported sporadically. Moreover, the malformative or tumoral nature is still debated. Because a sub...

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Main Authors: Tauziède-Espariat, Arnault (Author) , Masliah-Planchon, Julien (Author) , Sievers, Philipp (Author) , Sahm, Felix (Author) , Dangouloff-Ros, Volodia (Author) , Boddaert, Nathalie (Author) , Hasty, Lauren (Author) , Aboubakr, Oumaima (Author) , Métais, Alice (Author) , Chrétien, Fabrice (Author) , Roux, Alexandre (Author) , Pallud, Johan (Author) , Blauwblomme, Thomas (Author) , Beccaria, Kévin (Author) , Bourdeaut, Franck (Author) , Puget, Stéphanie (Author) , Varlet, Pascale (Author)
Format: Article (Journal)
Language:English
Published: Nov 2024
In: Brain pathology
Year: 2024, Volume: 34, Issue: 6, Pages: 1-11
ISSN:1750-3639
DOI:10.1111/bpa.13259
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/bpa.13259
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.13259
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Author Notes:Arnault Tauziède-Espariat, Julien Masliah-Planchon, Philipp Sievers, Felix Sahm, Volodia Dangouloff-Ros, Nathalie Boddaert, Lauren Hasty, Oumaima Aboubakr, Alice Métais, Fabrice Chrétien, Alexandre Roux, Johan Pallud, Thomas Blauwblomme, Kévin Beccaria, Franck Bourdeaut, Stéphanie Puget, Pascale Varlet
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Summary:Meningioangiomatosis (MAM) remains a poorly understood lesion responsible for epileptic disease. In the past, MAM was primarily described in the context of neurofibromatosis type 2 before being mainly reported sporadically. Moreover, the malformative or tumoral nature is still debated. Because a subset of MAM are associated with meningiomas, some authors argue that MAM corresponds to an infiltration pattern of these tumors. For these reasons, MAM has not been added to the World Health Organization (WHO) Classification of Central Nervous System Tumors as a specific entity. In the present study, we characterized a series of pure MAM (n = 7) and MAM associated with meningiomas (n = 4) using histopathology, immunohistochemistry, genetic (fluorescent in situ and DNA sequencing analyses), and epigenetic (DNA-methylation profiling) data. We evidenced two distinct morphological patterns: MAM with a fibroblastic-like pattern having few lesional cells, and MAM with a more cellular pattern. A subset was associated with the genetic alterations previously reported in meningiomas (such as a KMT2C mutation and a hemizygous deletion of chromosome 22q including the NF2 gene). The DNA-methylation profile, using a t-distributed stochastic neighbor embedding analysis, evidenced that MAM (pure or associated with meningiomas) clustered in a separate group from pediatric meningiomas. The present results seem to suggest that MAM represents a neoplastic lesion and encourage the further study of similar additional series so that it may be included in a future WHO classification.
Item Description:Gesehen am 01.07.2024
Physical Description:Online Resource
ISSN:1750-3639
DOI:10.1111/bpa.13259

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