Letter to the editor: vaccination against upper respiratory infections is a matter of survival in alcoholic liver disease$ppostscript : letters
We read with great interest the report on SARS-CoV-2 infection in patients with primary biliary cholangitis (PBC) by Ampuero et al .1 An independent association of chronic liver disease with adverse clinical outcome in patients with COVID-19 was previously reported in this journal.2 However, the imp...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
January 2023
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| In: |
Gut
Year: 2023, Volume: 72, Issue: 1, Pages: 208-209 |
| ISSN: | 1468-3288 |
| DOI: | 10.1136/gutjnl-2022-327086 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1136/gutjnl-2022-327086 Verlag, kostenfrei, Volltext: http://gut.bmj.com/content/72/1/208 
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| Author Notes: | Timo Itzel, Thomas Falconer, Jimmy Daza, Ana Roig, Jimyung Park, Jae Youn Cheong, Rae Woong Park, Isabella Wiest, Matthias Ebert, George Hripcsak, Andreas Teufel |
| Summary: | We read with great interest the report on SARS-CoV-2 infection in patients with primary biliary cholangitis (PBC) by Ampuero et al .1 An independent association of chronic liver disease with adverse clinical outcome in patients with COVID-19 was previously reported in this journal.2 However, the impact of SARS-CoV-2 and upper airway infections in general on patients with alcoholic liver disease (ALD) remains widely unknown. Yet, those data would be of high relevance to global public health and vaccination campaigns since alcohol related diseases are endemic. 57% of the population over age 15 has consumed alcohol in the last 12 months, and 2.3 billion people are current drinkers.3 - - With respect to upper airway respiratory infections, patients with chronic liver disease, including those with ALD, are particularly susceptible to infections as the immune system is dysfunctional through several pathological mechanisms including decreased opsonisation, reticuloendothelial dysfunction, neutrophils impairment and abnormal immunoglobulin synthesis.4 5 Moreover, alcohol abuse, independently from other factors, depresses the immune system by decreasing the lymphocytes and antibodies and the production of cytokines as TNF-alpha, IL-1 and IL-6.6 Several human and murine studies … |
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| Item Description: | Gesehen am 01.07.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1468-3288 |
| DOI: | 10.1136/gutjnl-2022-327086 |