Low rate of function-limiting side effects with high-dose adjuvant radiotherapy in high-grade soft tissue extremity sarcomas: a retrospective single-center analysis over 10 years
Over the years, radiotherapy has been established as a tool to improve local control for high-grade sarcomas. Although the European Society for Medical Oncology guidelines has taken notice of a shift toward a neoadjuvant radiotherapy approach, the American Society for Radiation Oncology guidelines c...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 2023
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| In: |
Journal of cancer research and clinical oncology
Year: 2023, Volume: 149, Issue: 8, Pages: 4877-4888 |
| ISSN: | 1432-1335 |
| DOI: | 10.1007/s00432-022-04423-1 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00432-022-04423-1 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00432-022-04423-1 
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| Author Notes: | Muemtaz Koeksal, Maike van der Hoek, Davide Scafa, David Koch, Christina Leitzen, Leonard C. Schmeel, Georg Feldmann, Andreas Strauss, Sebastian Koob, Frank A. Giordano |
| Summary: | Over the years, radiotherapy has been established as a tool to improve local control for high-grade sarcomas. Although the European Society for Medical Oncology guidelines has taken notice of a shift toward a neoadjuvant radiotherapy approach, the American Society for Radiation Oncology guidelines clearly favor a neoadjuvant approach, citing debilitating long-term adverse effects when radiotherapy is applied postoperatively. In this study, we examined these irradiation-associated adverse events for adjuvant radiotherapy and focused on the prognostic factors for disease outcome, including local control. |
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| Item Description: | Online veröffentlicht: 26. Oktober 2022 Gesehen am 01.07.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1335 |
| DOI: | 10.1007/s00432-022-04423-1 |