Neurocognitive changes at different follow-up times after bilateral subthalamic nucleus deep brain stimulation in patients with Parkinson's disease
Background - Bilateral deep thalamic nucleus brain stimulation (STN-DBS) surgery is often used to treat the motor symptoms of patients with Parkinson's disease. The change of neurocognitive symptoms in patients is, however, still unclear. - Objective - We aimed at analyzing the deterioration of...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 February 2024
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| In: |
Heliyon
Year: 2024, Volume: 10, Issue: 4, Pages: 1-13 |
| ISSN: | 2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e26303 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.heliyon.2024.e26303 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S240584402402334X 
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| Author Notes: | Zhuohang Wang, Zijian Zheng, Junwen Huang, Xu Cai, Xinjie Liu, Cheng Xue, Longping Yao, Guohui Lu |
| Summary: | Background - Bilateral deep thalamic nucleus brain stimulation (STN-DBS) surgery is often used to treat the motor symptoms of patients with Parkinson's disease. The change of neurocognitive symptoms in patients is, however, still unclear. - Objective - We aimed at analyzing the deterioration of neurocognitive symptoms in patients with Parkinson's disease after deep brain stimulation surgery under different follow-up times. - Methods - A comprehensive literature review was conducted using Pubmed, Cochrane Library, and Web of Science to screen eligible study records, the meta-analysis was performed using an inverse variance method and a random-effects model. Additionally, the areas of analysis include five: cognition, executive function, memory capacity, and verbal fluency (phonetic fluency and semantic fluency). They were analyzed for changes at six and twelve months postoperatively compared to baseline. The Meta-analysis has been registered with PROSPERO under the registration number: CRD42022308786. - Results - In terms of overall cognitive performance, executive function, and memory capacity, the original studies show a trend of improvement in these areas at 12 months postoperatively compared with 6 months, at variance, patients did not improve or deteriorated in phonetic fluency(d = −0.42 at both 6-month and 12-month follow-up) and semantic fluency from 6 to 12 months postoperatively. - Conclusion - In terms of most neurocognitive symptoms, including cognitive ability, executive function, and learning memory capacity, bilateral STN-DBS surgery appears to be safe at relatively long follow-up times. However, postoperative phonetic and semantic fluency changes should still not be underestimated, and clinicians should pay more attention to patients' changes in both. |
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| Item Description: | Online verfügbar: 10. Februar 2024, Artikelversion: 14. Februar 2024 Gesehen am 02.07.2024 |
| Physical Description: | Online Resource |
| ISSN: | 2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e26303 |