Change in choroidal nevi during a 5-year follow-up study: the Beijing Eye Study
Background To determine the risk of growth of presumed choroidal nevi in the adult Chinese population in Greater Beijing. - Methods The Beijing Eye Study is a population-based study that was performed in 2001 and in 2006. Of 126 subjects with presumed choroidal nevi detected in 2001, 75 (60%) subjec...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2010
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| In: |
British journal of ophthalmology
Year: 2010, Volume: 94, Issue: 5, Pages: 575-578 |
| ISSN: | 1468-2079 |
| DOI: | 10.1136/bjo.2009.165720 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1136/bjo.2009.165720 Verlag, lizenzpflichtig, Volltext: https://bjo.bmj.com/content/94/5/575 
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| Author Notes: | Qi Sheng You, Liang Xu, Jost B. Jonas, Shuang Wang, Hua Yang |
| Summary: | Background To determine the risk of growth of presumed choroidal nevi in the adult Chinese population in Greater Beijing. - Methods The Beijing Eye Study is a population-based study that was performed in 2001 and in 2006. Of 126 subjects with presumed choroidal nevi detected in 2001, 75 (60%) subjects returned for the follow-up examination and had readable fundus photographs available. To assess any change in size or shape of the nevi, we used flicker comparison of the fundus photographs. - Results An enlargement of the presumed choroidal nevi was detected in four eyes (5.3±22.6% (mean±SD); 95% CI 0.1 to 10.5%) during the 5-year follow-up. In another four eyes (5.3±22.6%; 95% CI 0.1 to 10.5%), drusen of the retinal pigment epithelium overlying the nevi increased in size. None of the nevi regressed in size or showed clinical signs indicating a malignant transformation. The ages of the four participants with an increase in the nevus size were 43, 45, 46 and 56 years at baseline; best corrected visual acuity was 1.0 and frequency doubling perimetry results were normal. - Conclusions Only a small percentage of adult Chinese participants aged ≥40 years showed an enlargement of presumed choroidal nevi during a follow-up period of 5 years. Taking into consideration that most of the study participants were already past the age of highest risk of developing a uveal melanoma in Chinese people, the results suggest a low risk of growth of choroidal nevi into malignant choroidal melanomas in Chinese people. |
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| Item Description: | Published online first 12 October 2009 Gesehen am 03.07.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1468-2079 |
| DOI: | 10.1136/bjo.2009.165720 |