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Post-transplant recurrence of focal segmental glomerular sclerosis: consensus statements

Focal segmental glomerular sclerosis (FSGS) is 1 of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease. Recurrence of FSGS after kidney transplantation significantly increases allograft loss, leading to morbidity and mortality. C...

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Main Authors: Raina, Rupesh (Author) , Jothi, Swathi (Author) , Haffner, Dieter (Author) , Somers, Michael (Author) , Filler, Guido (Author) , Vasistha, Prabhav (Author) , Chakraborty, Ronith (Author) , Shapiro, Ron (Author) , Randhawa, Parmjeet S. (Author) , Parekh, Rulan (Author) , Licht, Christopher (Author) , Bunchman, Timothy (Author) , Sethi, Sidharth (Author) , Mangat, Guneive (Author) , Zaritsky, Joshua (Author) , Schaefer, Franz (Author) , Warady, Bradley (Author) , Bartosh, Sharon (Author) , McCulloch, Mignon (Author) , Alhasan, Khalid (Author) , Swiatecka-Urban, Agnieszka (Author) , Smoyer, William E. (Author) , Chandraker, Anil (Author) , Yap, Hui Kim (Author) , Jha, Vivekanand (Author) , Bagga, Arvind (Author) , Radhakrishnan, Jai (Author)
Format: Article (Journal)
Language:English
Published: March 2024
In: Kidney international
Year: 2024, Volume: 105, Issue: 3, Pages: 450-463
ISSN:1523-1755
DOI:10.1016/j.kint.2023.10.017
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.kint.2023.10.017
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0085253823007652
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Author Notes:Rupesh Raina, Swathi Jothi, Dieter Haffner, Michael Somers, Guido Filler, Prabhav Vasistha, Ronith Chakraborty, Ron Shapiro, Parmjeet S. Randhawa, Rulan Parekh, Christopher Licht, Timothy Bunchman, Sidharth Sethi, Guneive Mangat, Joshua Zaritsky, Franz Schaefer, Bradley Warady, Sharon Bartosh, Mignon McCulloch, Khalid Alhasan, Agnieszka Swiatecka-Urban, William E. Smoyer, Anil Chandraker, Hui Kim Yap, Vivekanand Jha, Arvind Bagga and Jai Radhakrishnan
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Summary:Focal segmental glomerular sclerosis (FSGS) is 1 of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease. Recurrence of FSGS after kidney transplantation significantly increases allograft loss, leading to morbidity and mortality. Currently, there are no consensus guidelines for identifying those patients who are at risk for recurrence or for the management of recurrent FSGS. Our work group performed a literature search on PubMed/Medline, Embase, and Cochrane, and recommendations were proposed and graded for strength of evidence. Of the 614 initially identified studies, 221 were found suitable to formulate consensus guidelines for recurrent FSGS. These guidelines focus on the definition, epidemiology, risk factors, pathogenesis, and management of recurrent FSGS. We conclude that additional studies are required to strengthen the recommendations proposed in this review.
Item Description:Online verfügbar 22 December 2023, Version des Artikels 20 February 2024
Gesehen am 10.07.2024
Physical Description:Online Resource
ISSN:1523-1755
DOI:10.1016/j.kint.2023.10.017

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