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G Protein Coupled Receptor 87 (GPR87) in end stage kidney and associated tumors

Background/Aim: End-stage renal disease (ESRD) and acquired cystic renal disease (ACRD) are characterized by progressive inflammation, structural remodeling and by development of unique cancer types. Eosinophilic-vacuolated and chromophobe-like renal cell carcinoma develop exclusively in ACRD kidney...

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Bibliographic Details
Main Authors: Beöthe, Tamás (Author) , Kovacs, Gyula (Author) , Peterfi, Lehel (Author)
Format: Article (Journal)
Language:English
Published: February 2024
In: Anticancer research
Year: 2024, Volume: 44, Issue: 2, Pages: 555-559
ISSN:1791-7530
DOI:10.21873/anticanres.16843
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.16843
Verlag, lizenzpflichtig, Volltext: https://ar.iiarjournals.org/content/44/2/555-0
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Author Notes:Tamas Beothe, Gyula Kovacs, Lehel Peterfi
Description
Summary:Background/Aim: End-stage renal disease (ESRD) and acquired cystic renal disease (ACRD) are characterized by progressive inflammation, structural remodeling and by development of unique cancer types. Eosinophilic-vacuolated and chromophobe-like renal cell carcinoma develop exclusively in ACRD kidney. The aim of the study was to investigate the molecular mechanism of ESRD/ACRD carcinogenesis. Materials and Methods: Our previous Affymetrix array analysis detected GPR87 as one of the highly and specifically expressed genes in ESRD/ACRD kidneys. In this study we analyzed normal and ESRD/ACRD kidneys and related tumors for GPR87 expression by PCR, RT-PCR, and immunohistochemistry. Results: Immunohistochemistry revealed a strong GPR87 expression in proliferating epithelial cells in ESRD/ACRD kidneys and in cells of eosinophilic-vacuolated and chromophobe-like renal cell carcinoma. Conclusion: GPR87 signaling plays an important role in the structural remodeling of ESRD/ACRD kidney and development of ACRD-associated tumors with unique histology.
Item Description:Online veröffentlicht: 2. Februar 2024
Gesehen am 22.07.2024
Physical Description:Online Resource
ISSN:1791-7530
DOI:10.21873/anticanres.16843

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