Incidence, prevalence, and real-world treatment patterns in chronic myeloid leukemia: results from a population-representative German claims data analysis
Introduction: Real-world data on usage of 1st-, 2nd-, and 3rd-generation tyrosine kinase inhibitor (TKI) in chronic myeloid leukemia (CML) are scarce. This study therefore aimed to analyze the use of different TKIs used in 1st- and 2nd-line treatment and the frequency of TKI switches in CML. Methods...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2022
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| In: |
Oncology research and treatment
Year: 2022, Volume: 45, Issue: 7-8, Pages: 400-406 |
| ISSN: | 2296-5262 |
| DOI: | 10.1159/000524284 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000524284 Verlag, lizenzpflichtig, Volltext: https://karger.com/ort/article/45/7-8/400/826105/Incidence-Prevalence-and-Real-World-Treatment 
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| Author Notes: | Susanne Saußele, Katharina Kohlbrenner, Tobias Vogelmann, Tino Schubert |
| Summary: | Introduction: Real-world data on usage of 1st-, 2nd-, and 3rd-generation tyrosine kinase inhibitor (TKI) in chronic myeloid leukemia (CML) are scarce. This study therefore aimed to analyze the use of different TKIs used in 1st- and 2nd-line treatment and the frequency of TKI switches in CML. Methods: This observational study was based on the InGef research database, an anonymized representative claims dataset in Germany (n = 4 million). An incidence and prevalence patient CML cohort was followed for 5 and 3 years. Analyses regarding incidence, prevalence, and therapy distribution were performed descriptively. Results: 151 patients were included in the incidence and 636 patients in the prevalence cohort. This resulted in an incidence of 1.8 (95% confidence interval [CI]: 1.34-2.20) and a prevalence of 14.9 (95% CI: 13.70-16.03) per 100,000 inhabitants. For the incidence cohort, data on 1st-line therapy were available for 124 patients and distributed across imatinib (N = 52), nilotinib (N = 44), dasatinib (N = 12), chemotherapies as hydroxycarbamide (N = 11), and ponatinib/bosutinib (N = 5). Twenty-six percent of patients switched TKI therapy at least once in 3 years. In the prevalence cohort, 423 patients (66.5%) had claims on existing or newly emerged cardiovascular diseases (CDs). No significant differences (p = 0.32) between TKIs in patients with CD were found. Discussion: Every fourth patient switched TKI therapy within the first 3 years after treatment initiation. Switches were more likely when hints of disease progression or intolerability were observable in the database. |
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| Item Description: | Online veröffentlicht: 25. März 2022 Gesehen am 23.07.2024 |
| Physical Description: | Online Resource |
| ISSN: | 2296-5262 |
| DOI: | 10.1159/000524284 |