Cover Image

Cognitive Behavioral Therapy for late-life depression (CBTlate): results of a multicenter, randomized, observer-blinded, controlled trial

Introduction: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. Objective: The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison w...

Full description

Saved in:
Bibliographic Details
Main Authors: Dafsari, Forugh Salimi (Author) , Bewernick, Bettina (Author) , Böhringer, Sabine (Author) , Domschke, Katharina (Author) , Elsaeßer, Moritz (Author) , Löbner, Margrit (Author) , Luppa, Melanie (Author) , Preis, Lukas (Author) , Püsken, Julia (Author) , Schmitt, Sandra (Author) , Szekely, Andreea-Johanna (Author) , Hellmich, Martin (Author) , Müller, Wiebke (Author) , Wagner, Michael (Author) , Peters, Oliver (Author) , Frölich, Lutz (Author) , Riedel-Heller, Steffi Gerlinde (Author) , Schramm, Elisabeth (Author) , Hautzinger, Martin (Author) , Jessen, Frank (Author)
Format: Article (Journal)
Language:English
Published: June 2023
In: Psychotherapy and psychosomatics
Year: 2023, Volume: 92, Issue: 3, Pages: 180-192
ISSN:1423-0348
DOI:10.1159/000529445
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000529445
Verlag, lizenzpflichtig, Volltext: https://karger.com/pps/article/92/3/180/835896/Cognitive-Behavioral-Therapy-for-Late-Life
Get full text
Author Notes:Forugh S. Dafsari, Bettina Bewernick, Sabine Böhringer, Katharina Domschke, Moritz Elsaesser, Margrit Löbner, Melanie Luppa, Lukas Preis, Julia Püsken, Sandra Schmitt, Andreea-Johanna Szekely, Martin Hellmich, Wiebke Müller, Michael Wagner, Oliver Peters, Lutz Frölich, Steffi Riedel-Heller, Elisabeth Schramm, Martin Hautzinger, Frank Jessen
Description
Summary:Introduction: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. Objective: The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting. Methods: In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up. Results: Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: −1.01 [95% CI: −2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms. Conclusions: Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.
Item Description:Online veröffentlicht: June 27 2023
Gesehen am 29.07.2024
Physical Description:Online Resource
ISSN:1423-0348
DOI:10.1159/000529445

Similar Items