Cognitive Behavioral Therapy for late-life depression (CBTlate): results of a multicenter, randomized, observer-blinded, controlled trial
Introduction: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. Objective: The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison w...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2023
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| In: |
Psychotherapy and psychosomatics
Year: 2023, Jahrgang: 92, Heft: 3, Pages: 180-192 |
| ISSN: | 1423-0348 |
| DOI: | 10.1159/000529445 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000529445 Verlag, lizenzpflichtig, Volltext: https://karger.com/pps/article/92/3/180/835896/Cognitive-Behavioral-Therapy-for-Late-Life 
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| Verfasserangaben: | Forugh S. Dafsari, Bettina Bewernick, Sabine Böhringer, Katharina Domschke, Moritz Elsaesser, Margrit Löbner, Melanie Luppa, Lukas Preis, Julia Püsken, Sandra Schmitt, Andreea-Johanna Szekely, Martin Hellmich, Wiebke Müller, Michael Wagner, Oliver Peters, Lutz Frölich, Steffi Riedel-Heller, Elisabeth Schramm, Martin Hautzinger, Frank Jessen |
MARC
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| 245 | 1 | 0 | |a Cognitive Behavioral Therapy for late-life depression (CBTlate) |b results of a multicenter, randomized, observer-blinded, controlled trial |c Forugh S. Dafsari, Bettina Bewernick, Sabine Böhringer, Katharina Domschke, Moritz Elsaesser, Margrit Löbner, Melanie Luppa, Lukas Preis, Julia Püsken, Sandra Schmitt, Andreea-Johanna Szekely, Martin Hellmich, Wiebke Müller, Michael Wagner, Oliver Peters, Lutz Frölich, Steffi Riedel-Heller, Elisabeth Schramm, Martin Hautzinger, Frank Jessen |
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| 520 | |a Introduction: Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. Objective: The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting. Methods: In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up. Results: Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT (n = 126) or SUI (n = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: −1.01 [95% CI: −2.88 to 0.86]; p = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms. Conclusions: Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT. | ||
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