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Region-specific rnhancement of c-fos expression by combined treatment with NMDA receptor agonists and antagonists with antidepressant potential: brief report

Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in combination with the global and GluN2B subunit-specific NMDAR...

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Main Authors: Vasilescu, Andrei-Nicolae (Author) , Pfeiffer, Natascha (Author) , Terraneo, Federica (Author) , Riva, Marco Andrea (Author) , Lang, Undine E (Author) , Inta, Dragos (Author) , Gass, Peter (Author)
Format: Article (Journal)
Language:English
Published: November 2022
In: The international journal of neuropsychopharmacology
Year: 2022, Volume: 25, Issue: 11, Pages: 946-950
ISSN:1469-5111
DOI:10.1093/ijnp/pyac051
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ijnp/pyac051
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/ijnp/article/25/11/946/6668855?login=true
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Author Notes:Andrei-Nicolae Vasilescu, Natascha Pfeiffer, Federica Terraneo, Marco Andrea Riva, Undine E. Lang, Dragos Inta, Peter Gass
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Summary:Rapastinel, formerly Glyx-13, is a novel positive allosteric modulator of the N-methyl-D-aspartate-receptor (NMDAR) that counteracts psychotomimetic actions of NMDAR antagonists. We set out to evaluate the effect of rapastinel alone or in combination with the global and GluN2B subunit-specific NMDAR antagonists MK-801 and Ro25-6981, respectively, on neuronal activation in relevant regions using c-fos brain mapping. Whereas rapastinel alone did not trigger significant c-fos expression beyond the prelimbic cortex, it strongly increased the c-fos expression induced by MK-801 in hippocampal, cingulate, and retrosplenial areas. Similar results were obtained when rapastinel was replaced by D-cycloserine. Our results reveal new interactions at network level between NMDAR modulators with possible implications regarding their therapeutic effects.
Item Description:Artikel veröffentlicht: 17. August 2022
Gesehen am 30.07.2024
Physical Description:Online Resource
ISSN:1469-5111
DOI:10.1093/ijnp/pyac051

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