High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany

Low-density lipoprotein cholesterol (LDL-C) is the main therapeutic target in the treatment of hypercholesterolemia. Small interfering RNA (siRNA) inclisiran is a new drug, which targets PCSK9 mRNA in the liver, reducing concentrations of circulating LDL-C. In randomized trials, inclisiran demonstra...

Full description

Bibliographic Details

Main Authors:	Makhmudova, Umidakhon (Author) , Schatz, U. (Author) , Perakakis, N. (Author) , Kassner, U. (Author) , Schumann, F. (Author) , Axthelm, C. (Author) , Stürzebecher, P. (Author) , Sinning, D. L. (Author) , Doevelaar, A. (Author) , Rohn, B. (Author) , Westhoff, T. (Author) , Vogt, A. (Author) , Scholl, M. (Author) , Kästner, U. (Author) , Geiling, J.-A. (Author) , Stach-Jablonski, Ksenija (Author) , Mensch, J. (Author) , Lorenz, E. (Author) , Paitazoglou, C. (Author) , Eitel, I. (Author) , Baessler, A. (Author) , Steinhagen-Thiessen, E. (Author) , Koenig, W. (Author) , Schulze, P. C. (Author) , Landmesser, U. (Author) , Laufs, U. (Author) , Weingärtner, Oliver (Author)
Format:	Article (Journal)
Language:	English
Published:	November 2023
In:	Clinical research in cardiology Year: 2023, Volume: 112, Issue: 11, Pages: 1639-1649
ISSN:	1861-0692
DOI:	10.1007/s00392-023-02247-8
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00392-023-02247-8 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00392-023-02247-8
Author Notes:	U. Makhmudova, U. Schatz, N. Perakakis, U. Kassner, F. Schumann, C. Axthelm, P. Stürzebecher, D. L. Sinning, A. Doevelaar, B. Rohn, T. Westhoff, A. Vogt, M. Scholl, U. Kästner, J.-A. Geiling, K. Stach, J. Mensch, E. Lorenz, C. Paitazoglou, I. Eitel, A. Baessler, E. Steinhagen-Thiessen, W. Koenig, P. C. Schulze, U. Landmesser, U. Laufs, Oliver Weingärtner, for the German Inclisiran Network (GIN)