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COVID-19 infection in patients with history of pediatric heart transplant in Germany, Austria, and Switzerland

COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric h...

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Main Authors: Ulrich, Sarah (Author) , Balmer, Christian (Author) , Becker, Kolja (Author) , Bruhs, Josefin (Author) , Danne, Friederike (Author) , Debus, Volker (Author) , Dewein, Leonie (Author) , Di-Bernardo, Stefano (Author) , Doll, Ulrike (Author) , Fleck, Thilo (Author) , Tirilomis, Theodor (Author) , Glockler, Martin (Author) , Grafmann, Maria (Author) , Greil, Sabine (Author) , Grosser, Urte (Author) , Saur, Patrick (Author) , Skrzypek, Susanne (Author) , Steinmetz, Michael (Author)
Format: Article (Journal)
Language:English
Published: March 2024
In: Clinical transplantation
Year: 2024, Volume: 38, Issue: 3, Pages: 1-7
ISSN:1399-0012
DOI:10.1111/ctr.15272
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ctr.15272
Verlag, kostenfrei, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1111%2Fctr.15272&DestApp=DOI&SrcAppSID=EUW1ED0CE5hHp47VRxNYj6cUZ94Id&SrcJTitle=CLINICAL+TRANSPLANTATION&DestDOIRegistrantName=Wiley+%28Blackwell+Publishing%29
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Author Notes:Sarah Ulrich, Christian Balmer, Kolja Becker, Josefin Bruhs, Friederike Danne, Volker Debus, Leonie Dewein, Stefano Di-Bernardo, Ulrike Doll, Thilo Fleck, Theodor Tirilomis, Martin Glockler, Maria Grafmann, Sabine Greil, Urte Grosser, Patrick Saur, Susanne Skrzypek, Michael Steinmetz, on behalf of the Working group thoracic organ transplantation DGPK
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Summary:COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric heart transplant centers in Germany, Austria and Switzerland to evaluate the risk of a severe COVID-19 infection after pediatric heart transplantation between 02/2020 and 06/2021. Twenty-six subjects (11 male) with a median age of 9.77 years at time of transplantation and a median of 4.65 years after transplantation suffered from COVID-19 infection. The median age at time of COVID-10 infection was 17.20 years. Fourteen subjects had an asymptomatic COVID-19 infection. The most frequent symptoms were myalgia/fatigue (n = 6), cough (n = 5), rhinitis (n = 5), and loss of taste (n = 5). Only one subject showed dyspnea. Eleven individuals needed therapy in an outpatient setting, four subjects were hospitalized. One person needed oxygen supply, none of the subjects needed non-invasive or invasive mechanical ventilation. No specific signs for graft dysfunction were found by non-invasive testing. In pediatric heart transplant subjects, COVID-19 infection was mostly asymptomatic or mild. There were no SARS-CoV-2 associated myocardial dysfunction in heart transplant individuals.
Item Description:Zuerst veröffentlicht: 06. März 2024
Gesehen am 02.08.2024
Physical Description:Online Resource
ISSN:1399-0012
DOI:10.1111/ctr.15272

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