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COVID-19 infection in patients with history of pediatric heart transplant in Germany, Austria, and Switzerland

COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric h...

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Hauptverfasser: Ulrich, Sarah (VerfasserIn) , Balmer, Christian (VerfasserIn) , Becker, Kolja (VerfasserIn) , Bruhs, Josefin (VerfasserIn) , Danne, Friederike (VerfasserIn) , Debus, Volker (VerfasserIn) , Dewein, Leonie (VerfasserIn) , Di-Bernardo, Stefano (VerfasserIn) , Doll, Ulrike (VerfasserIn) , Fleck, Thilo (VerfasserIn) , Tirilomis, Theodor (VerfasserIn) , Glockler, Martin (VerfasserIn) , Grafmann, Maria (VerfasserIn) , Greil, Sabine (VerfasserIn) , Grosser, Urte (VerfasserIn) , Saur, Patrick (VerfasserIn) , Skrzypek, Susanne (VerfasserIn) , Steinmetz, Michael (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: March 2024
In: Clinical transplantation
Year: 2024, Jahrgang: 38, Heft: 3, Pages: 1-7
ISSN:1399-0012
DOI:10.1111/ctr.15272
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ctr.15272
Verlag, kostenfrei, Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1111%2Fctr.15272&DestApp=DOI&SrcAppSID=EUW1ED0CE5hHp47VRxNYj6cUZ94Id&SrcJTitle=CLINICAL+TRANSPLANTATION&DestDOIRegistrantName=Wiley+%28Blackwell+Publishing%29
Volltext
Verfasserangaben:Sarah Ulrich, Christian Balmer, Kolja Becker, Josefin Bruhs, Friederike Danne, Volker Debus, Leonie Dewein, Stefano Di-Bernardo, Ulrike Doll, Thilo Fleck, Theodor Tirilomis, Martin Glockler, Maria Grafmann, Sabine Greil, Urte Grosser, Patrick Saur, Susanne Skrzypek, Michael Steinmetz, on behalf of the Working group thoracic organ transplantation DGPK
Beschreibung
Zusammenfassung:COVID-19 is a heterogenous infection-asymptomatic to fatal. While the course of pediatric COVID-19 infections is usually mild or even asymptomatic, individuals after adult heart transplantation are at high risk of a severe infection. We conducted a retrospective, multicenter survey of 16 pediatric heart transplant centers in Germany, Austria and Switzerland to evaluate the risk of a severe COVID-19 infection after pediatric heart transplantation between 02/2020 and 06/2021. Twenty-six subjects (11 male) with a median age of 9.77 years at time of transplantation and a median of 4.65 years after transplantation suffered from COVID-19 infection. The median age at time of COVID-10 infection was 17.20 years. Fourteen subjects had an asymptomatic COVID-19 infection. The most frequent symptoms were myalgia/fatigue (n = 6), cough (n = 5), rhinitis (n = 5), and loss of taste (n = 5). Only one subject showed dyspnea. Eleven individuals needed therapy in an outpatient setting, four subjects were hospitalized. One person needed oxygen supply, none of the subjects needed non-invasive or invasive mechanical ventilation. No specific signs for graft dysfunction were found by non-invasive testing. In pediatric heart transplant subjects, COVID-19 infection was mostly asymptomatic or mild. There were no SARS-CoV-2 associated myocardial dysfunction in heart transplant individuals.
Beschreibung:Zuerst veröffentlicht: 06. März 2024
Gesehen am 02.08.2024
Beschreibung:Online Resource
ISSN:1399-0012
DOI:10.1111/ctr.15272

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