Supracategorical fear information revealed by aversively conditioning multiple categories
Fear-generalization is a critical function for survival, in which an organism extracts information from a specific instantiation of a threat (e.g., the western diamondback rattlesnake in my front yard on Sunday) and learns to fear - and accordingly respond to - pertinent higher-order information (e....
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2021
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| In: |
Cognitive neuroscience
Year: 2021, Volume: 12, Issue: 1, Pages: 28-39 |
| ISSN: | 1758-8936 |
| DOI: | 10.1080/17588928.2020.1839039 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1080/17588928.2020.1839039 Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.1080/17588928.2020.1839039 
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| Author Notes: | Seth M Levine, Miriam Kumpf, Rainer Rupprecht and Jens V Schwarzbach |
| Summary: | Fear-generalization is a critical function for survival, in which an organism extracts information from a specific instantiation of a threat (e.g., the western diamondback rattlesnake in my front yard on Sunday) and learns to fear - and accordingly respond to - pertinent higher-order information (e.g., snakes live in my yard). Previous work investigating fear-conditioning in humans has used functional magnetic resonance imaging (fMRI) to demonstrate that activity patterns representing stimuli from an aversively-conditioned category (CS+) are more similar to each other than those of a neutral category (CS-). Here we used fMRI and multiple aversively-conditioned categories to ask whether we would find only similarity increases within the CS+ categories or also similarity increases between the CS+ categories. Using representational similarity analysis, we correlated several models to activity patterns underlying different brain regions and found that, following fear-conditioning, between-category and within-category similarity increased for the CS+ categories in the insula, superior frontal gyrus (SFG), and the right temporal pole. When specifically investigating fear-generalization, these between- and within-category effects were detected in the SFG. These results advance prior pattern-based neuroimaging work by exploring the effect of aversively-conditioning multiple categories and indicate an extended role for such regions in potentially representing supracategorical information during fear-learning. |
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| Item Description: | Online veröffentlicht: 1. November 2020 Gesehen am 05.08.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1758-8936 |
| DOI: | 10.1080/17588928.2020.1839039 |