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Adolescents’ pain-related ontogeny shares a neural basis with adults’ chronic pain in basothalamo-cortical organization

During late adolescence, the brain undergoes ontogenic organization altering subcortical-cortical circuitry. This includes regions implicated in pain chronicity, and thus alterations in the adolescent ontogenic organization could predispose to pain chronicity in adulthood - however, evidence is lack...

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Main Authors: Heukamp, Nils (Author) , Banaschewski, Tobias (Author) , Bokde, Arun L. W. (Author) , Desrivières, Sylvane (Author) , Grigis, Antoine (Author) , Garavan, Hugh (Author) , Gowland, Penny (Author) , Heinz, Andreas (Author) , Kandić, Mina (Author) , Brühl, Rüdiger (Author) , Martinot, Jean-Luc (Author) , Paillère Martinot, Marie-Laure (Author) , Artiges, Eric (Author) , Papadopoulos Orfanos, Dimitri (Author) , Lemaitre, Herve (Author) , Löffler, Martin (Author) , Poustka, Luise (Author) , Hohmann, Sarah (Author) , Millenet, Sabina (Author) , Fröhner, Juliane (Author) , Smolka, Michael (Author) , Usai, Katrin (Author) , Vaidya, Nilakshi (Author) , Walter, Henrik (Author) , Whelan, Robert (Author) , Schumann, Gunter (Author) , Flor, Herta (Author) , Nees, Frauke (Author)
Format: Article (Journal)
Language:English
Published: 16 February 2024
In: iScience
Year: 2024, Volume: 27, Issue: 2, Pages: 1-15
ISSN:2589-0042
DOI:10.1016/j.isci.2024.108954
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.isci.2024.108954
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2589004224001755
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Author Notes:Nils Jannik Heukamp, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivières, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Mina Kandić, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Dimitri Papadopoulos Orfanos, Herve Lemaitre, Martin Löffler, Luise Poustka, Sarah Hohmann, Sabina Millenet, Juliane H. Fröhner, Michael N. Smolka, Katrin Usai, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Frauke Nees, and IMAGEN Consortium
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Summary:During late adolescence, the brain undergoes ontogenic organization altering subcortical-cortical circuitry. This includes regions implicated in pain chronicity, and thus alterations in the adolescent ontogenic organization could predispose to pain chronicity in adulthood - however, evidence is lacking. Using resting-state functional magnetic resonance imaging from a large European longitudinal adolescent cohort and an adult cohort with and without chronic pain, we examined links between painful symptoms and brain connectivity. During late adolescence, thalamo-, caudate-, and red nucleus-cortical connectivity were positively and subthalamo-cortical connectivity negatively associated with painful symptoms. Thalamo-cortical connectivity, but also subthalamo-cortical connectivity, was increased in adults with chronic pain compared to healthy controls. Our results indicate a shared basis in basothalamo-cortical circuitries between adolescent painful symptomatology and adult pain chronicity, with the subthalamic pathway being differentially involved, potentially due to a hyperconnected thalamo-cortical pathway in chronic pain and ontogeny-driven organization. This can inform neuromodulation-based prevention and early intervention.
Item Description:Online verfügbar: 17. Januar 2024, Artikelversion: 31. Januar 2024
Gesehen am 06.08.2024
Physical Description:Online Resource
ISSN:2589-0042
DOI:10.1016/j.isci.2024.108954

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