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Interaction of tumor‑associated macrophages with stromal and immune components in solid tumors: research progress (Review)

Tumor‑associated macrophages (TAMs) are crucial cells of the tumor microenvironment (TME), which belong to the innate immune system and regulate primary tumor growth, immunosuppression, angiogenesis, extracellular matrix remodeling and metastasis. The review discusses current knowledge of essential...

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Hauptverfasser: Kazakova, Anna (VerfasserIn) , Sudarskikh, Tatiana (VerfasserIn) , Kovalev, Oleg (VerfasserIn) , Kzhyshkowska, Julia (VerfasserIn) , Larionova, Irina (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February-2023
In: International journal of oncology
Year: 2023, Jahrgang: 62, Heft: 2, Pages: 1-21
ISSN:1791-2423
DOI:10.3892/ijo.2023.5480
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3892/ijo.2023.5480
Verlag, kostenfrei, Volltext: https://www.spandidos-publications.com/10.3892/ijo.2023.5480
Volltext
Verfasserangaben:Anna Kazakova, Tatiana Sudarskikh, Oleg Kovalev, Julia Kzhyshkowska, Irina Larionova
Beschreibung
Zusammenfassung:Tumor‑associated macrophages (TAMs) are crucial cells of the tumor microenvironment (TME), which belong to the innate immune system and regulate primary tumor growth, immunosuppression, angiogenesis, extracellular matrix remodeling and metastasis. The review discusses current knowledge of essential cell‑cell interactions of TAMs within the TME of solid tumors. It summarizes the mechanisms of stromal cell (including cancer‑associated fibroblasts and endothelial cells)‑mediated monocyte recruitment and regulation of differentiation, as well as pro‑tumor and antitumor polarization of TAMs. Additionally, it focuses on the perivascular TAM subpopulations that regulate angiogenesis and lymphangiogenesis. It describes the possible mechanisms of reciprocal interactions of TAMs with other immune cells responsible for immunosuppression. Finally, it highlights the perspectives for novel therapeutic approaches to use combined cellular targets that include TAMs and other stromal and immune cells in the TME. The collected data demonstrated the importance of understanding cell‑cell interactions in the TME to prevent distant metastasis and reduce the risk of tumor recurrence.
Beschreibung:Online veröffentlicht: 16. Januar 2023
Gesehen am 08.08.2024
Beschreibung:Online Resource
ISSN:1791-2423
DOI:10.3892/ijo.2023.5480

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