DNA and mRNA sequence of the immune protective DNA Iigase I gene match the rev response element of HIV
A motif search for DNA and mRNA sequences matching the rev response core element of HIV identified only DNA ligase I to display the element both in DNA and mRNA and to have phylo-genetic conservation of it. Genetic impairment of DNA ligase I is already known to lead to severe immunodeficiency in man...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1996
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| In: |
DNA sequence
Year: 1996, Volume: 6, Issue: 2, Pages: 119-121 |
| ISSN: | 1029-2365 |
| DOI: | 10.3109/10425179609010198 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/10425179609010198
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| Author Notes: | Thomas Dandekar, Gudrun Koch |
| Summary: | A motif search for DNA and mRNA sequences matching the rev response core element of HIV identified only DNA ligase I to display the element both in DNA and mRNA and to have phylo-genetic conservation of it. Genetic impairment of DNA ligase I is already known to lead to severe immunodeficiency in man. A similar impairment may result from HIV rev protein binding to the DNA ligase I mRNA. |
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| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 11. Juli 2009 Gesehen am 08.08.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1029-2365 |
| DOI: | 10.3109/10425179609010198 |