Ab initio tertiary-fold prediction of helical and non-helical protein chains using a genetic algorithm
In this study, protein structures were predicted using a genetic algorithm. Optimal structures were selected according to basic protein-building principles. Having previously applied this approach to proteins with helical topology, this paper reports preliminary results on 3 proteins with mixed topo...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 1996
|
| In: |
International journal of biological macromolecules
Year: 1996, Volume: 18, Issue: 1, Pages: 1-4 |
| ISSN: | 1879-0003 |
| DOI: | 10.1016/0141-8130(95)01036-X |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0141-8130(95)01036-X Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/014181309501036X 
|
| Author Notes: | T. Dandekar, P. Argos |
| Summary: | In this study, protein structures were predicted using a genetic algorithm. Optimal structures were selected according to basic protein-building principles. Having previously applied this approach to proteins with helical topology, this paper reports preliminary results on 3 proteins with mixed topology (helical and non-helical, e.g. sheet). The method seems to be generally applicable to protein-fold prediction since topology predictions close to the observed experimental structures are obtained. |
|---|---|
| Item Description: | Elektronische Reproduktion der Druck-Ausgabe 1. Dezember 1999 Gesehen am 08.08.2024 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0003 |
| DOI: | 10.1016/0141-8130(95)01036-X |